Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.34 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21728222 | 0.81 | CYP3A4 (0.39) | CYP3A4TAAR1SMN1; SMN2TP53MRGPRX4 | |
| SCHEMBL6447941 | 0.81 | CYP3A4 (0.42) | CYP3A4SMN1; SMN2TP53MRGPRX4POLB | |
| SCHEMBL98215 | 0.81 | TAAR1 (0.57) | TAAR1TP53POLBGAAUSP2 | |
| SCHEMBL27860623 | 0.81 | TDP1 (0.41) | CYP3A4SMN1; SMN2TP53POLBLMNA | |
| SCHEMBL25192903 | 0.78 | NOS3 (0.37) | CYP3A4SMN1; SMN2LMNAUSP2TDP1 | |
| SCHEMBL29952456 | 0.78 | CYP3A4 (0.38) | CYP3A4TAAR1SMN1; SMN2TP53GAA | |
| SCHEMBL7519481 | 0.78 | ALOX15 (0.57) | CYP3A4SMN1; SMN2POLBLMNAUSP2 | |
| SCHEMBL21157263 | 0.77 | KDM4E (0.42) | CYP3A4SMN1; SMN2POLBGAAHTR2A | |
| SCHEMBL585624 | 0.77 | IDO1 (0.50) | CYP3A4TAAR1TDP1IDO1HPGD | |
| SCHEMBL16245816 | 0.76 | TAAR1 (0.35) | TAAR1SMN1; SMN2TP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| CN-1061034-C | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMA (JP) | 2001-01-24 | — | — | CN | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |