Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.77 |
| ▸ | FLT1 | P17948 | 4/20 | 0.68 |
| ▸ | FLT4 | P35916 | 4/20 | 0.68 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.43 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550295 | 0.93 | KDR (0.78) | KDRFLT1FLT4PRKCBPRKCA | |
| SCHEMBL7551441 | 0.91 | KDR (0.71) | KDRFLT1FLT4FLT3CNR2 | |
| SCHEMBL7502516 | 0.90 | KDR (0.77) | KDRFLT1FLT4CNR2CNR1 | |
| SCHEMBL7553508 | 0.89 | KDR (0.69) | KDRFLT1FLT4FLT3CNR2 | |
| SCHEMBL7555221 | 0.88 | KDR (0.68) | KDRFLT1FLT4FLT3 | |
| SCHEMBL7555564 | 0.88 | KDR (0.62) | KDRFLT1FLT4FLT3CNR2 | |
| SCHEMBL7555743 | 0.88 | KDR (0.62) | KDRFLT1FLT4FLT3 | |
| SCHEMBL7556531 | 0.87 | KDR (1.00) | KDRFLT1FLT4FLT3CNR2 | |
| SCHEMBL7549908 | 0.87 | KDR (1.00) | KDRFLT1FLT4FLT3CNR2 | |
| SCHEMBL7554226 | 0.87 | KDR (0.66) | KDRFLT1FLT4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | claimed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1147107-A4 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO INC (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-1147107-A1 | NOVEL ANGIOGENESIS INHIBITORS | Merck & Co., Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000043393-A1 | NOVEL ANGIOGENESIS INHIBITORS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |