Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6343569 | 0.92 | PTGS2 (0.69) | PTGS2PTGS1SMN1; SMN2CA1CA2 | |
| SCHEMBL8315280 | 0.89 | PTGS2 (0.74) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL8317861 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1SMN1; SMN2CA12CA1 | |
| SCHEMBL8317359 | 0.86 | PTGS2 (0.83) | PTGS2PTGS1SMN1; SMN2CA12CA1 | |
| SCHEMBL6338963 | 0.84 | PTGS2 (0.56) | PTGS2PTGS1SMN1; SMN2CA1CA2 | |
| SCHEMBL8317163 | 0.84 | PTGS2 (0.84) | PTGS2PTGS1SMN1; SMN2CA12CA1 | |
| SCHEMBL7550669 | 0.84 | PTGS2 (0.73) | PTGS2PTGS1SMN1; SMN2CA12CA1 | |
| SCHEMBL6338962 | 0.82 | SMN1; SMN2 (0.76) | PTGS2PTGS1SMN1; SMN2CA9 | |
| SCHEMBL6339300 | 0.81 | PTGS2 (0.71) | PTGS2PTGS1 | |
| SCHEMBL6353925 | 0.81 | PTGS2 (0.69) | PTGS2PTGS1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923933-B1 | Substituted pyrazolyl benzenesulfonamides for use in the treatment of inflammation | SEARLE & CO (US) | 2002-07-03 | — | — | EP | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |