Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6342176 | 0.92 | PTGS2 (0.67) | PTGS2PTGS1SMN1; SMN2CA1CA2 | |
| SCHEMBL8315280 | 0.91 | PTGS2 (0.74) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL8317861 | 0.84 | PTGS2 (1.00) | PTGS2PTGS1SMN1; SMN2CA1CA2 | |
| SCHEMBL7550702 | 0.84 | PTGS2 (0.75) | PTGS2PTGS1SMN1; SMN2CA1CA2 | |
| SCHEMBL6353925 | 0.83 | PTGS2 (0.69) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8317163 | 0.83 | PTGS2 (0.84) | PTGS2PTGS1SMN1; SMN2CA1CA2 | |
| SCHEMBL8317359 | 0.82 | PTGS2 (0.83) | PTGS2PTGS1SMN1; SMN2CA1CA2 | |
| SCHEMBL8860043 | 0.82 | PTGS2 (0.64) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8317147 | 0.77 | PTGS2 (0.80) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL6343569 | 0.76 | PTGS2 (0.69) | PTGS2PTGS1SMN1; SMN2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923933-B1 | Substituted pyrazolyl benzenesulfonamides for use in the treatment of inflammation | SEARLE & CO (US) | 2002-07-03 | — | — | EP | claimed |
| EP-0731795-B1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 1999-12-22 | — | — | EP | claimed |
| CN-1202828-A | Substituted pyrzolyl benzenesulfonanides for use in veterinary | SEARLE & CO (US) | 1998-12-23 | — | — | CN | claimed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | claimed |
| CN-1141630-A | Substituted pyrazolyl benzenesulfonamides for treating inflammation | SEARLE & CO (US) | 1997-01-29 | — | — | CN | claimed |
| CN-101242875-A | Ophthalmic composition containing mucoadhesive polysaccharides capable of promoting corneal re-epithelialization | OPOCRIN SPA (IT) | 2008-08-13 | — | — | CN | disclosed |
| CN-1137134-C | Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors | ���µ�˹ҩ�﹫˾ | 2004-02-04 | — | — | CN | disclosed |
| CN-1127484-C | Substituted pyrazolyl benzene sulfone amides compounds for curing inflammation | SEARLE & CO (US) | 2003-11-12 | — | — | CN | disclosed |
| CN-1339020-A | Process for producing vitamin | DCV INC (US) | 2002-03-06 | — | — | CN | disclosed |
| CN-1280126-A | Substituted pyrazolyl benzenesulfonamides for treating inflammation | SEARLE & CO (US) | 2001-01-17 | — | — | CN | disclosed |
| CN-1280125-A | Substituted pyrazolyl benzene sulfone amides compounds for curing inflammation | SEARLE & CO (US) | 2001-01-17 | — | — | CN | disclosed |
| CN-1202828-A | Substituted pyrzolyl benzenesulfonanides for use in veterinary | SEARLE & CO (US) | 1998-12-23 | — | — | CN | disclosed |
| US-5760068-A | NONSTEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G.D. SEARLE & CO. (US) | 1998-06-02 | — | — | US | disclosed |
| US-5756529-A | ANTIINFLAMMATORY | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| CN-1141630-A | Substituted pyrazolyl benzenesulfonamides for treating inflammation | SEARLE & CO (US) | 1997-01-29 | — | — | CN | disclosed |