Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 12/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.48 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7551539 | 1.00 | PNMT (0.48) | PNMTADRA2AADRA2BADRA2CASIC3 | |
| SCHEMBL3748263 | 0.84 | PNMT (0.45) | PNMTADRA2AADRA2BADRA2CASIC3 | |
| SCHEMBL13631383 | 0.77 | PNMT (0.58) | PNMTADRA2AADRA2BADRA2CKDM1A | |
| SCHEMBL25800726 | 0.77 | PNMT (0.58) | PNMTADRA2AADRA2BADRA2CASIC3 | |
| SCHEMBL6839690 | 0.77 | PNMT (0.58) | PNMTADRA2AADRA2BADRA2CKDM1A | |
| SCHEMBL419457 | 0.77 | CA1 (0.50) | PNMTADRA2AADRA2BADRA2CKDM1A | |
| SCHEMBL615229 | 0.77 | CA1 (0.50) | PNMTADRA2AADRA2BADRA2CKDM1A | |
| SCHEMBL13227654 | 0.77 | PNMT (0.49) | PNMTADRA2AADRA2BADRA2CASIC3 | |
| SCHEMBL419456 | 0.77 | CA1 (0.50) | PNMTADRA2AADRA2BADRA2CKDM1A | |
| Hydrochloric Acid SCHEMBL22092770 | 0.76 | CA1 (0.52) | PNMTADRA2AADRA2BADRA2CKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259484-A1 | CARBOXAMIDES USEFUL AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND OF APOLIPOPROTEIN B SECRETION | Novartis AG (CH) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001053260-A1 | CARBOXAMIDES USEFUL AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND OF APOLIPOPROTEIN B SECRETION | NOVARTIS AG (CH) | 2001-07-26 | — | — | WO | disclosed |