Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 12/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.43 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7551539 | 0.84 | PNMT (0.48) | PNMTADRA2AADRA2BADRA2CASIC3 | |
| SCHEMBL7551545 | 0.84 | PNMT (0.48) | PNMTADRA2AADRA2BADRA2CASIC3 | |
| SCHEMBL4758601 | 0.77 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CASIC3 | |
| SCHEMBL2892133 | 0.77 | CYP1A2 (0.49) | PNMTADRA2AADRA2BADRA2CASIC3 | |
| SCHEMBL6407573 | 0.77 | CYP1A2 (0.49) | PNMTADRA2AADRA2BADRA2CASIC3 | |
| SCHEMBL354979 | 0.77 | OPRK1 (0.62) | OPRK1 | |
| SCHEMBL354978 | 0.77 | OPRK1 (0.62) | OPRK1 | |
| SCHEMBL3020673 | 0.77 | OPRK1 (0.62) | OPRK1 | |
| SCHEMBL9071241 | 0.77 | PNMT (0.51) | PNMTADRA2AADRA2BADRA2CASIC3 | |
| Hydrochloric Acid SCHEMBL4117494 | 0.76 | OPRK1 (0.61) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188273-A2 | NOVEL SUBSTITUTED TETRAHYDRONAPHTHALENES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS MEDICAMENTS | Sanofi-Aventis (FR) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009021740-A2 | SUBSTITUTED TETRAHYDRONAPHTHALENES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS MEDICAMENTS | SANOFIS-AVENTIS (FR) | 2009-02-19 | — | — | WO | disclosed |