Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9604071 | 0.80 | PIK3CD (0.53) | L3MBTL1HIF1APIK3CGPIK3CD | |
| SCHEMBL10296667 | 0.75 | L3MBTL1 (0.58) | L3MBTL1HIF1APIK3CGPIK3CD | |
| SCHEMBL13781780 | 0.73 | PIK3CD (0.45) | MAPTL3MBTL1HIF1APIK3CGPIK3CD | |
| SCHEMBL13781779 | 0.72 | PIK3CD (0.49) | L3MBTL1PIK3CGPIK3CD | |
| SCHEMBL935071 | 0.70 | PIK3CD (0.47) | L3MBTL1PIK3CGPIK3CD | |
| SCHEMBL935601 | 0.70 | PIK3CD (0.48) | L3MBTL1PIK3CGPIK3CD | |
| SCHEMBL18708426 | 0.70 | PIK3CD (0.53) | L3MBTL1PIK3CGPIK3CD | |
| SCHEMBL29479409 | 0.70 | PIK3CD (0.48) | L3MBTL1PIK3CGPIK3CD | |
| SCHEMBL18199848 | 0.69 | ALDH1A1 (0.50) | MAPTMAPK1L3MBTL1HIF1APIK3CG | |
| SCHEMBL935507 | 0.69 | PIK3CD (0.45) | MAPTL3MBTL1PIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138195-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138195-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2012-03-20 | — | — | US | disclosed |