SCHEMBL755192

SCHEMBL755192

Cn1c(=NN)sc2cc(S(=O)(=O)O)ccc21

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.47
RXFP1 Q9HBX9 6/20 0.46
NPC1 O15118 6/20 0.46
RAB9A P51151 6/20 0.46
KDM4E B2RXH2 3/20 0.46
ALDH1A1 P00352 3/20 0.46
MAPT P10636 3/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
LMNA P02545 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
TP53 P04637 1/20 0.43
ATM Q13315 1/20 0.42
HPGD P15428 1/20 0.41
POLB P06746 1/20 0.39
THRB P10828 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1827490 1.00 TSHR (0.50) TSHRL3MBTL1RXFP1NPC1RAB9A
SCHEMBL30084525 1.00 TSHR (0.50) TSHRL3MBTL1RXFP1NPC1RAB9A
SCHEMBL11385267 0.90 TSHR (0.51) TSHRL3MBTL1RXFP1NPC1RAB9A
SCHEMBL4613895 0.88 NPC1 (0.40) TSHRL3MBTL1RXFP1NPC1RAB9A
SCHEMBL4613896 0.88 NPC1 (0.40) TSHRL3MBTL1RXFP1NPC1RAB9A
SCHEMBL5279659 0.83 TSHR (0.46) TSHRL3MBTL1RXFP1NPC1RAB9A
SCHEMBL5279665 0.83 TSHR (0.46) TSHRL3MBTL1RXFP1NPC1RAB9A
SCHEMBL4615225 0.83 TSHR (0.46) TSHRL3MBTL1RXFP1NPC1RAB9A
SCHEMBL4615224 0.83 TSHR (0.46) TSHRL3MBTL1RXFP1NPC1RAB9A
SCHEMBL11277936 0.79 MAPT (0.45) TSHRL3MBTL1RXFP1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2319937-B1 BLOOD COMPONENT MEASUREMENT METHOD UTILIZING HEMOLYZED WHOLE BLOOD, AND KIT FOR THE METHOD NIPPON KAYAKU KK (JP) 2016-01-27 EP claimed
US-8883439-B2 Blood component measurement method utilizing hemolyzed whole blood, and kit for the method NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2014-11-11 US claimed
US-20110165608-A1 BLOOD COMPONENT MEASUREMENT METHOD UTILIZING HEMOLYZED WHOLE BLOOD, AND KIT FOR THE METHOD NIPPON KAYAKU KABUSHIKI KAISHA (JP) 2011-07-07 US claimed
EP-2319937-A1 BLOOD COMPONENT MEASUREMENT METHOD UTILIZING HEMOLYZED WHOLE BLOOD, AND KIT FOR THE METHOD Nippon Kayaku Kabushiki Kaisha (JP) 2011-05-11 EP claimed
US-7429274-B2 Agent and method for the oxidative coloring of keratin fibers WELLA AG (DE) 2008-09-30 US claimed
EP-1601335-B1 MEANS AND METHOD FOR THE SIMULTANEOUS BLEACHING AND DYEING OF KERATIN FIBRES WELLA AG (DE) 2008-03-19 EP claimed
EP-1699427-B1 AGENT AND METHOD FOR OXIDATIVELY DYING KERATIN FIBERS WELLA AG (DE) 2008-02-27 EP claimed
US-7326254-B2 Means and method for the simultaneous bleaching and dyeing of keratin fibres WELLA AG (DE) 2008-02-05 US claimed
US-7291183-B2 Agent and method for dyeing keratin fibers WELLA AG (DE) 2007-11-06 US claimed
US-7244278-B2 Agent and method for oxidative coloring of keratin fibers WELLA AG (DE) 2007-07-17 US claimed
US-20060162096-A1 Means and method for the simultaneous bleaching and dyeing of keratin fibres HFC PRESTIGE INTERNATIONAL HOLDING SWITZERLAND S.A.R.L (CH) 2006-07-27 US claimed
US-20060010616-A1 Agent and method for dyeing keratin fibers Wella GmbH (DE) 2006-01-19 US claimed
EP-1601335-A1 MEANS AND METHOD FOR THE SIMULTANEOUS BLEACHING AND DYEING OF KERATIN FIBRES Wella Aktiengesellschaft (DE) 2005-12-07 EP claimed
EP-1599179-A1 AGENT AND METHOD FOR DYEING KERATIN FIBRES Wella Aktiengesellschaft (DE) 2005-11-30 EP claimed
WO-2005060928-A1 AGENT AND METHOD FOR OXIDATIVELY DYING KERATIN FIBERS WELLA AKTIENGESELLSCHAFT (DE) 2005-07-07 WO claimed
WO-2005060927-A1 AGENT AND METHOD FOR OXIDATIVELY DYEING KERATIN FIBERS WELLA AKTIENGESELLSCHAFT (DE) 2005-07-07 WO claimed
WO-2004078152-A1 MEANS AND METHOD FOR THE SIMULTANEOUS BLEACHING AND DYEING OF KERATIN FIBRES WELLA AKTIENGESELLSCHAFT (DE) 2004-09-16 WO claimed
WO-2004078153-A1 AGENT AND METHOD FOR DYEING KERATIN FIBRES WELLA AKTIENGESELLSCHAFT (DE) 2004-09-16 WO claimed
EP-0068356-B1 REAGENT AND METHOD FOR DETECTING HYDROGEN PEROXIDE OR PEROXIDASES Roche Diagnostics GmbH (DE) 1986-09-10 EP claimed
US-4492754-A Composition and method for the determination of hydrogen peroxide BOEHRINGER MANNHEIM GMBH (DE) 1985-01-08 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060162096-A1 Means and method for the simultaneous bleaching and dyeing of keratin fibres KRT18, GPX4, NOX4 TSHR 2086/4885L3MBTL1 4866/4885RXFP1 3668/4885
US-20060010616-A1 Agent and method for dyeing keratin fibers KRT18, KIT, MKI67 TSHR 4464/4885L3MBTL1 4881/4885RXFP1 3978/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.