SCHEMBL755249

SCHEMBL755249

O=C(O)/C=C\c1cccnc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.76
MAPT P10636 2/20 0.76
KDM4E B2RXH2 2/20 0.76
NPC1 O15118 2/20 0.76
JUN P05412 1/20 0.76
NFKB1 P19838 1/20 0.76
MAPK1 P28482 1/20 0.76
GPR55 Q9Y2T6 1/20 0.76
PFKFB3 Q16875 1/20 0.65
CYP1A1 P04798 6/20 0.62
CYP1A2 P05177 6/20 0.62
CYP1B1 Q16678 6/20 0.62
TBXAS1 P24557 2/20 0.62
CYP11B1 P15538 1/20 0.62
CYP11B2 P19099 1/20 0.62
KMT2A Q03164 1/20 0.61
HDAC3 O15379 1/20 0.61
TNKS O95271 1/20 0.61
HDAC4 P56524 1/20 0.61
HDAC1 Q13547 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL334614 1.00 RAB9A (0.76) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL334615 1.00 RAB9A (0.76) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL29416684 1.00 RAB9A (0.76) RAB9AMAPTKDM4ENPC1JUN
Hydrochloric Acid SCHEMBL27850886 0.98 RAB9A (0.73) RAB9AMAPTKDM4ENPC1JUN
Hydrochloric Acid SCHEMBL10810828 0.98 RAB9A (0.73) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL10898888 0.98 RAB9A (0.73) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL8801611 0.87 RAB9A (0.59) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL6642060 0.87 RAB9A (0.59) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL6642064 0.87 RAB9A (0.59) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL5468278 0.87 MAPT (0.64) RAB9AMAPTKDM4ENPC1JUN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2431502-B1 CYANIDE-FREE SILVER ELECTROPLATING SOLUTIONS ROHM & HAAS ELECT MAT (US) 2017-05-24 EP claimed
US-8608932-B2 Cyanide-free silver electroplating solutions ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2013-12-17 US claimed
US-20120067735-A1 CYANIDE-FREE SILVER ELECTROPLATING SOLUTIONS ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2012-03-22 US claimed
EP-2431502-A2 Cyanide-free silver electroplating solutions Rohm and Haas Electronic Materials LLC (US) 2012-03-21 EP claimed
US-20240217932-A1 PYRIDIUM ESTERS THE PROCTER AND GAMBLE COMPANY 2024-07-04 US disclosed
EP-4374698-A1 PYRIDINIUM ESTERS The Procter & Gamble Company (US) 2024-05-29 EP disclosed
EP-3704094-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY Calico Life Sciences LLC (US) 2020-09-09 EP disclosed
US-9994558-B2 Multicyclic compounds and methods of using same Karyopharm Therapeutics Inc. (US) 2018-06-12 US disclosed
US-9994558-B2 Multicyclic compounds and methods of using same Karyopharm Therapeutics Inc. (US) 2018-06-12 US disclosed
US-9994558-B2 Multicyclic compounds and methods of using same Karyopharm Therapeutics Inc. (US) 2018-06-12 US disclosed
EP-2431502-B1 CYANIDE-FREE SILVER ELECTROPLATING SOLUTIONS ROHM & HAAS ELECT MAT (US) 2017-05-24 EP disclosed
US-20170096417-A1 Multicyclic Compounds And Methods Of Using Same Karyopharm Therapeutics Inc. (US) 2017-04-06 US disclosed
US-20170096417-A1 Multicyclic Compounds And Methods Of Using Same Karyopharm Therapeutics Inc. (US) 2017-04-06 US disclosed
US-20170096417-A1 Multicyclic Compounds And Methods Of Using Same Karyopharm Therapeutics Inc. (US) 2017-04-06 US disclosed
WO-2015042414-A1 MULTICYCLIC COMPOUNDS AND METHODS OF USING SAME Karyopharm Therapeutics Inc. (US) 2015-03-26 WO disclosed
WO-2015042414-A1 MULTICYCLIC COMPOUNDS AND METHODS OF USING SAME Karyopharm Therapeutics Inc. (US) 2015-03-26 WO disclosed
CN-103717574-A Novel compounds and compositions for the inhibition of nampt FORMA TM LLC 2014-04-09 CN disclosed
US-8608932-B2 Cyanide-free silver electroplating solutions ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2013-12-17 US disclosed
US-20120067735-A1 CYANIDE-FREE SILVER ELECTROPLATING SOLUTIONS ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2012-03-22 US disclosed
EP-2431502-A2 Cyanide-free silver electroplating solutions Rohm and Haas Electronic Materials LLC (US) 2012-03-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170096417-A1 Multicyclic Compounds And Methods Of Using Same PAK4, PAK5, PAK1 RAB9A 487/4885MAPT 1510/4885KDM4E 611/4885
US-20240217932-A1 PYRIDIUM ESTERS C5, CBR3, CHRM1 RAB9A 3949/4885MAPT 4762/4885KDM4E 1739/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.