Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.54 |
| ▸ | HTR7 | P34969 | 6/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.54 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14282338 | 0.83 | ACHE (0.60) | DRD2SLC6A4 | |
| SCHEMBL7649258 | 0.83 | HTR2A (0.55) | HTR2AHTR7KCNH2DRD2SLC6A4 | |
| SCHEMBL28972651 | 0.82 | ACHE (0.59) | DRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL9075374 | 0.81 | DRD2 (0.65) | HTR2AHTR7KCNH2DRD2SLC6A4 | |
| SCHEMBL28522063 | 0.81 | DRD2 (0.62) | HTR2AHTR7KCNH2DRD2SLC6A4 | |
| SCHEMBL28522065 | 0.81 | DRD2 (0.62) | HTR2AHTR7KCNH2DRD2SLC6A4 | |
| SCHEMBL1545147 | 0.80 | ACHE (0.61) | DRD2SLC6A4 | |
| SCHEMBL7505737 | 0.80 | HTR2A (0.56) | HTR2AHTR7KCNH2 | |
| Alcohol SCHEMBL7723583 | 0.77 | DRD2 (0.65) | HTR2AHTR7KCNH2DRD2SLC6A4 | |
| SCHEMBL1545753 | 0.77 | ACHE (0.73) | HTR2AHTR7KCNH2DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455531-B1 | METALLOPROTEINASE INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2002-09-24 | — | — | US | disclosed |
| EP-1237868-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | Darwin Discovery Limited (GB) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001044189-A1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |