Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTPRA | P18433 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507123 | 0.81 | HPGD (0.67) | SMN1; SMN2RAB9AHPGDHSD17B10CTSK | |
| SCHEMBL7545282 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AHPGDHSD17B10 | |
| SCHEMBL30890579 | 0.80 | HPGD (0.65) | SMN1; SMN2RAB9AHPGDHSD17B10GAA | |
| SCHEMBL6440706 | 0.79 | HPGD (0.54) | SMN1; SMN2NPC1RAB9AHPGDHSD17B10 | |
| SCHEMBL5086307 | 0.78 | HDAC6 (0.49) | HPGDHSD17B10HDAC6HDAC1CTSK | |
| SCHEMBL16118686 | 0.75 | HSD17B10 (0.49) | HPGDHSD17B10HDAC6HDAC1ALDH1A1 | |
| SCHEMBL9694059 | 0.73 | HPGD (0.56) | SMN1; SMN2NPC1RAB9AHPGDHSD17B10 | |
| SCHEMBL9695556 | 0.73 | HPGD (0.56) | SMN1; SMN2NPC1RAB9AHPGDHSD17B10 | |
| SCHEMBL9691525 | 0.73 | HPGD (0.56) | SMN1; SMN2NPC1RAB9AHPGDHSD17B10 | |
| SCHEMBL9695155 | 0.73 | HPGD (0.56) | SMN1; SMN2NPC1RAB9AHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212301-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016107-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2001-03-08 | — | — | WO | disclosed |