Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7548169 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9ALMNAHPGD | |
| SCHEMBL7552785 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9ALMNAHPGD | |
| SCHEMBL8507123 | 0.80 | HPGD (0.67) | SMN1; SMN2RAB9AHPGDHSD17B10CTSK | |
| SCHEMBL30890579 | 0.79 | HPGD (0.65) | SMN1; SMN2RAB9AHPGDHSD17B10GAA | |
| SCHEMBL6440706 | 0.78 | HPGD (0.54) | SMN1; SMN2NPC1RAB9ALMNAHPGD | |
| SCHEMBL23585702 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ALMNAHPGD | |
| SCHEMBL7277280 | 0.73 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9ALMNAHPGD | |
| SCHEMBL9691525 | 0.72 | HPGD (0.56) | SMN1; SMN2NPC1RAB9AHPGDHSD17B10 | |
| SCHEMBL9695155 | 0.72 | HPGD (0.56) | SMN1; SMN2NPC1RAB9AHPGDHSD17B10 | |
| SCHEMBL9695556 | 0.72 | HPGD (0.56) | SMN1; SMN2NPC1RAB9AHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212301-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016107-A1 | ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2001-03-08 | — | — | WO | disclosed |