SCHEMBL7552891

SCHEMBL7552891

NCCCOCc1cccnc1

nearest known ligand 0.61

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.61
HRH1 P35367 2/20 0.57
CHRNA7 P36544 1/20 0.55
CHRNB2 P17787 4/20 0.48
CHRNA4 P43681 4/20 0.48
CHRM2 P08172 3/20 0.48
CHRM1 P11229 3/20 0.48
CHRM3 P20309 3/20 0.48
CYP3A4 P08684 1/20 0.44
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
TDP1 Q9NUW8 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
HSD11B1 P28845 1/20 0.42
HRH4 Q9H3N8 1/20 0.41
HRH3 Q9Y5N1 1/20 0.41
HTR1A P08908 1/20 0.41
DRD2 P14416 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2565875 0.89 CHRNA7 (0.58) CYP2A6HRH1CHRNA7CHRNB2CHRNA4
SCHEMBL17713225 0.86 CHRNA7 (0.55) CYP2A6HRH1CHRNA7CHRNB2CHRNA4
SCHEMBL20412275 0.85 CYP2A6 (0.74) CYP2A6HRH1CHRNA7CYP3A4CYP1A2
SCHEMBL7546154 0.83 CHRNB2 (0.48) CYP2A6HRH1CHRNA7CHRNB2CHRNA4
SCHEMBL8904555 0.83 CHRM2 (0.48) CYP2A6HRH1CHRNA7CHRNB2CHRNA4
SCHEMBL493020 0.81 CYP1A2 (0.56) CYP2A6HRH1CHRNA7CHRNB2CHRNA4
SCHEMBL28856610 0.80 L3MBTL1 (0.60) HRH1CHRNB2CHRNA4CHRM2CHRM1
SCHEMBL18389623 0.80 HRH1 (0.73) CYP2A6HRH1CHRNA7CYP3A4CYP2D6
SCHEMBL13610217 0.80 L3MBTL1 (0.60) HRH1CHRNB2CHRNA4CHRM2CHRM1
Hydrochloric Acid SCHEMBL27794086 0.79 CYP1A2 (0.54) CYP2A6CHRNA7CHRNB2CHRNA4CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1212301-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS Targacept, Inc. (US) 2002-06-12 EP disclosed
WO-2001016107-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2001-03-08 WO disclosed