Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | CCR4 | P51679 | 3/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3588890 | 0.80 | ADRA2C (0.36) | CCR4SMN1; SMN2ALDH1A1KDM4EGFER | |
| SCHEMBL6971975 | 0.73 | DRD3 (0.57) | DRD3DRD2HTR1ADRD4HTR2A | |
| SCHEMBL21590165 | 0.71 | MAPT (0.47) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL6972658 | 0.71 | DRD2 (0.46) | DRD3DRD2CCR4SIRT6ALDH1A1 | |
| SCHEMBL3601316 | 0.69 | ADRA2C (0.42) | DRD3DRD2HTR1ADRD4HTR2A | |
| SCHEMBL21447973 | 0.69 | DRD3 (0.56) | DRD3DRD2HTR1ADRD4HTR2A | |
| SCHEMBL21448005 | 0.69 | DRD3 (0.56) | DRD3DRD2HTR1ADRD4HTR2A | |
| SCHEMBL285241 | 0.69 | DRD2 (0.60) | DRD3DRD2HTR1ADRD4HTR2A | |
| SCHEMBL9523246 | 0.69 | DRD3 (0.56) | DRD3DRD2HTR1ADRD4HTR2A | |
| SCHEMBL2481218 | 0.69 | DRD2 (0.56) | DRD3DRD2HTR1ADRD4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946539-A1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1999-10-06 | — | — | EP | claimed |
| WO-1998027081-A1 | SULPHONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | SMITHKLINE BEECHAM PLC (GB) | 1998-06-25 | — | — | WO | claimed |