Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14364056 | 0.86 | POLB (0.55) | TP53POLBCYP1A2MAPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL1003649 | 0.84 | CYP1A2 (0.50) | TP53POLBCYP1A2MAPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL30546604 | 0.84 | CYP1A2 (0.50) | TP53POLBCYP1A2MAPTCYP2C9 | |
| SCHEMBL1258663 | 0.83 | POLB (0.51) | TP53POLBCYP1A2MAPTCYP2C9 | |
| SCHEMBL11081067 | 0.82 | MEN1 (0.60) | CYP1A2MAPTHDAC1HDAC8HDAC6 | |
| SCHEMBL9653899 | 0.81 | MEN1 (0.58) | POLBCYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL11689863 | 0.80 | MAPT (0.48) | TP53POLBCYP1A2MAPTCYP2C9 | |
| SCHEMBL11427553 | 0.79 | MEN1 (0.53) | POLBCYP1A2MAPTCYP2C9CYP2C19 | |
| SCHEMBL11314855 | 0.78 | MAPT (0.62) | TP53POLBCYP1A2MAPTCYP2C9 | |
| SCHEMBL14900902 | 0.78 | POLB (0.72) | TP53POLBCYP1A2MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002066092-A2 | DRUG ELUTING DEVICE FOR TREATING VASCULAR DISEASES | ANGIOGENE INC. (CA) | 2002-08-29 | — | — | WO | claimed |
| US-20020119178-A1 | Drug eluting device for treating vascular diseases | LEVESQUE LUC (CA) | 2002-08-29 | — | — | US | claimed |
| WO-2002066092-A2 | DRUG ELUTING DEVICE FOR TREATING VASCULAR DISEASES | ANGIOGENE INC. (CA) | 2002-08-29 | — | — | WO | disclosed |
| US-20020119178-A1 | Drug eluting device for treating vascular diseases | LEVESQUE LUC (CA) | 2002-08-29 | — | — | US | disclosed |