Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 2/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.40 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7156591 | 0.90 | PDE5A (0.43) | PDE5AAURKAMETAP1METAP2ALDH1A1 | |
| SCHEMBL7553973 | 0.88 | PDE5A (0.53) | PDE5AAURKAMETAP1METAP2ADORA3 | |
| SCHEMBL7160066 | 0.86 | NPC1 (0.54) | ALDH1A1HPGDPKMKDM4ENPC1 | |
| SCHEMBL7153868 | 0.80 | METAP2 (0.48) | PDE5AAURKAMETAP1METAP2NPY5R | |
| SCHEMBL7553825 | 0.80 | HRH4 (0.53) | METAP1METAP2ADORA3ALDH1A1HPGD | |
| SCHEMBL7548148 | 0.79 | KDM4E (0.40) | PDE5AALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL7158379 | 0.79 | PDE5A (0.42) | PDE5AMETAP2ALDH1A1HPGDPKM | |
| SCHEMBL7553109 | 0.78 | NPC1 (0.51) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7548763 | 0.78 | PDE5A (0.43) | PDE5AAURKAMETAP1METAP2ADORA3 | |
| SCHEMBL7551054 | 0.78 | AURKA (0.71) | PDE5AAURKAMETAP1METAP2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020099054-A1 | 2-phenyl benzimidazole derivatives as MCP-1 antagonists | WARNER-LAMBERT COMPANY (US) | 2002-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099054-A1 | 2-phenyl benzimidazole derivatives as MCP-1 antagonists | CCR1, CCR2, CCR8 | PDE5A 3671/4885AURKA 4675/4885METAP1 1325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.