Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18248499 | 0.83 | NAAA (0.41) | POLBALDH1A1 | |
| SCHEMBL18248614 | 0.83 | NAAA (0.41) | POLBALDH1A1 | |
| SCHEMBL17593426 | 0.78 | ALOX5 (0.47) | NOS2TRPM8EPHX1MEN1KMT2A | |
| SCHEMBL8446344 | 0.78 | CYP1A2 (0.46) | NOS3NOS2TRPM8EPHX1MEN1 | |
| Hydrochloric Acid SCHEMBL17593603 | 0.77 | ALOX5 (0.46) | NOS2TRPM8EPHX1MEN1KMT2A | |
| SCHEMBL18248558 | 0.77 | SOAT1 (0.43) | MEN1KMT2ACYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL18248648 | 0.77 | SOAT1 (0.43) | MEN1KMT2ACYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL18248623 | 0.76 | CNR1 (0.44) | MEN1KMT2ALMNAALDH1A1CYP3A4 | |
| SCHEMBL7511823 | 0.75 | EPHX1 (0.45) | EPHX1POLBCYP1A2ALDH1A1PKM | |
| SCHEMBL503566 | 0.74 | CYP2D6 (0.43) | MEN1KMT2ALMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |