Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR3 | P25089 | 2/20 | 0.36 |
| ▸ | FPR2 | P25090 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7547784 | 0.96 | MTNR1A (0.34) | FPR3FPR2MTNR1AMTNR1BCACNA1B | |
| SCHEMBL7549043 | 0.91 | MTNR1A (0.33) | FPR3FPR2MTNR1AMTNR1BCACNA1B | |
| SCHEMBL7548909 | 0.89 | MTNR1A (0.32) | FPR3FPR2MTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL7551122 | 0.89 | MTNR1A (0.32) | FPR3FPR2MTNR1AMTNR1BCACNA1B | |
| SCHEMBL7550864 | 0.88 | MTNR1A (0.32) | FPR3FPR2MTNR1AMTNR1BCACNA1B | |
| SCHEMBL7550440 | 0.88 | MTNR1A (0.32) | FPR3FPR2MTNR1AMTNR1BNAMPT | |
| SCHEMBL7548639 | 0.87 | MTNR1A (0.32) | MTNR1AMTNR1BCACNA1BL3MBTL1NAMPT | |
| SCHEMBL7551444 | 0.82 | MTNR1A (0.34) | MTNR1AMTNR1BPRMT5WDR77MAPT | |
| SCHEMBL7550462 | 0.82 | MTNR1A (0.32) | MTNR1AMTNR1BL3MBTL1NAMPTROCK2 | |
| SCHEMBL7547267 | 0.82 | MTNR1A (0.32) | MTNR1AMTNR1BCACNA1BL3MBTL1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |