Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | ACACA | Q13085 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7549043 | 0.96 | MTNR1A (0.33) | MTNR1AMTNR1BL3MBTL1GAACACNA1B | |
| SCHEMBL7547784 | 0.92 | MTNR1A (0.34) | MTNR1AMTNR1BL3MBTL1CACNA1BNAMPT | |
| SCHEMBL7550462 | 0.90 | MTNR1A (0.32) | MTNR1AMTNR1BL3MBTL1ROCK2NAMPT | |
| SCHEMBL7547267 | 0.89 | MTNR1A (0.32) | MTNR1AMTNR1BL3MBTL1CACNA1BROCK2 | |
| SCHEMBL7547391 | 0.88 | MAPT (0.33) | MTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL7554385 | 0.88 | GLS (0.30) | MTNR1AMTNR1B | |
| SCHEMBL7554008 | 0.87 | FPR3 (0.36) | MTNR1AMTNR1BL3MBTL1GAACACNA1B | |
| SCHEMBL7548916 | 0.86 | GRIN1 (0.32) | L3MBTL1ROCK2NAMPTGRIN1GRIN2D | |
| SCHEMBL7549035 | 0.86 | MTNR1A (0.36) | MTNR1AMTNR1BL3MBTL1CACNA1BKDM4E | |
| SCHEMBL7550093 | 0.85 | PPARD (0.33) | L3MBTL1ROCK2GRIN1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |