Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.63 |
| ▸ | DRD3 | P35462 | 4/20 | 0.63 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485216 | 0.84 | DRD2 (0.56) | DRD2DRD3PLAUHTR6ANPEP | |
| SCHEMBL1682787 | 0.84 | DRD2 (0.56) | DRD2DRD3PLAUHTR6ANPEP | |
| SCHEMBL526993 | 0.79 | TBXA2R (0.55) | DRD2DRD3PLAUHTR6 | |
| SCHEMBL3318587 | 0.77 | DRD2 (1.00) | DRD2DRD3PLAUNFKB1THPO | |
| SCHEMBL265580 | 0.77 | DRD2 (1.00) | DRD2DRD3PLAUNFKB1THPO | |
| SCHEMBL11981410 | 0.77 | DRD2 (1.00) | DRD2DRD3PLAUNFKB1THPO | |
| SCHEMBL31681697 | 0.77 | DRD2 (1.00) | DRD2DRD3PLAUNFKB1THPO | |
| Bromide SCHEMBL10358294 | 0.76 | DRD2 (0.96) | DRD2DRD3PLAUNFKB1THPO | |
| SCHEMBL4024066 | 0.75 | DRD2 (0.66) | DRD2DRD3PLAUHTR6OPRK1 | |
| Hydrochloric Acid SCHEMBL9368920 | 0.74 | DRD3 (0.48) | DRD2DRD3PLAUHTR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970042-B1 | 5-HYDROXYMETHYL-2-AMINOTETRALINS AS CARDIOVASCULAR AGENTS | ZAMBON SPA (IT) | 2002-01-09 | — | — | EP | disclosed |
| US-6063964-A | 5-hydroxymethyl-2-aminotetralins as cardiovascular agents | ZAMBON GROUP S.P.A. (IT) | 2000-05-16 | — | — | US | disclosed |
| US-6063964-A | 5-hydroxymethyl-2-aminotetralins as cardiovascular agents | ZAMBON GROUP S.P.A. (IT) | 2000-05-16 | — | — | US | disclosed |
| EP-0970042-A1 | 5-HYDROXYMETHYL-2-AMINOTETRALINS AS CARDIOVASCULAR AGENTS | ZAMBON GROUP S.p.A. (IT) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998038155-A1 | 5-HYDROXYMETHYL-2-AMINOTETRALINS AS CARDIOVASCULAR AGENTS | ZAMBON GROUP S.P.A. (IT) | 1998-09-03 | — | — | WO | disclosed |