Sugi Predict

Sugi Predict / Compounds / SCHEMBL265580

SCHEMBL265580

SCHEMBL265580

NC1CCc2c(O)cccc2C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DRD2 P14416 7/20 1.00
▸ DRD3 P35462 7/20 1.00
▸ PLAU P00749 1/20 0.55
▸ MAPT P10636 2/20 0.52
▸ NFKB1 P19838 1/20 0.52
▸ THPO P40225 1/20 0.52
▸ HIF1A Q16665 1/20 0.52
▸ HSD17B10 Q99714 1/20 0.52
▸ USP2 O75604 1/20 0.52
▸ ALDH1A1 P00352 1/20 0.52
▸ DRD4 P21917 4/20 0.51
▸ HTR1A P08908 1/20 0.51
▸ DRD1 P21728 1/20 0.51
▸ DRD5 P21918 1/20 0.51
▸ HTR7 P34969 1/20 0.51
▸ ADRB2 P07550 1/20 0.51
▸ BCL2L1 Q07817 1/20 0.50
▸ BAD Q92934 1/20 0.50
▸ KDM4E B2RXH2 1/20 0.50
▸ CA1 P00915 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3318587 1.00 DRD2 (1.00) DRD2DRD3PLAUMAPTNFKB1
SCHEMBL11981410 1.00 DRD2 (1.00) DRD2DRD3PLAUMAPTNFKB1
SCHEMBL31681697 1.00 DRD2 (1.00) DRD2DRD3PLAUMAPTNFKB1
Bromide SCHEMBL10358294 0.98 DRD2 (0.96) DRD2DRD3PLAUMAPTNFKB1
SCHEMBL266906 0.85 DRD2 (0.74) DRD2DRD3PLAUMAPTNFKB1
SCHEMBL6688741 0.81 DRD2 (0.66) DRD2DRD3MAPTNFKB1THPO
SCHEMBL1261038 0.79 DRD2 (0.66) DRD2DRD3DRD4HTR1ADRD1
SCHEMBL13487690 0.79 DRD2 (0.66) DRD2DRD3DRD4HTR1ADRD1
SCHEMBL4024066 0.79 DRD2 (0.66) DRD2DRD3PLAUMAPTNFKB1
Hydrochloric Acid SCHEMBL7330966 0.78 DRD2 (0.64) DRD2DRD3PLAUMAPTNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116621775-A 2-amino-5-hydroxytetrahydronaphthalene derivative containing hydroxypyridone side chain, preparation and application thereof 浙江大学 2023-08-22 — — CN claimed
EP-0026848-A1 Derivatives of tetraline, their preparation and medicaments containing these compounds SANDOZ AG (CH) 1981-04-15 — — EP claimed
CN-116621775-B 2-Amino-5-hydroxytetrahydronaphthalene derivative containing hydroxypyridone side chain, preparation and application thereof 浙江大学 2025-09-09 — — CN disclosed
CN-116621775-A 2-amino-5-hydroxytetrahydronaphthalene derivative containing hydroxypyridone side chain, preparation and application thereof 浙江大学 2023-08-22 — — CN disclosed
CN-116621775-A 2-amino-5-hydroxytetrahydronaphthalene derivative containing hydroxypyridone side chain, preparation and application thereof 浙江大学 2023-08-22 — — CN disclosed
CN-116621775-A 2-amino-5-hydroxytetrahydronaphthalene derivative containing hydroxypyridone side chain, preparation and application thereof 浙江大学 2023-08-22 — — CN disclosed
US-11198685-B2 Substituted ureas and methods of making and using same MEBIAS DISCOVERY, INC. (US) 2021-12-14 — — US disclosed
US-20200308155-A1 Substituted Ureas and Methods of Making and Using Same MEBIAS DISCOVERY, INC. 2020-10-01 — — US disclosed
US-10683283-B2 Substituted ureas and methods of making and using same MEBIAS DISCOVERY, INC. (US) 2020-06-16 — — US disclosed
US-20170305877-A1 Processes for the Preparation of Rotigotine and Intermediates Thereof APOTEX INC. (CA) 2017-10-26 — — US disclosed
EP-2723727-B1 METHOD FOR INDUSTRIALLY PREPARING NITROGEN SUBSTITUTED AMINO-5,6,7,8-TETRAHYDRONAPHTHOL SHAN DONG LUYE PHARM CO LTD (CN) 2017-03-01 — — EP disclosed
US-5274003-A A 3-naphthyloxy- or -thioaklyleneamino-8-hydroxytetralin derivative WHITBY RESEARCH, INC. (US) 1993-12-28 — — US disclosed
US-5118704-A Treating disorders of central nervous, cardiovascular and endocrine systems WHITBY RESEARCH, INC. (US) 1992-06-02 — — US disclosed
EP-0463119-A4 SUBSTITUTED 2-AMINOTETRALINS — 1992-01-22 — — EP disclosed
EP-0463119-A1 use of SUBSTITUTED 2-AMINOTETRALINS for the preparation of a medicament for inducing anorexia or weight loss. Whitby Research Incorporated (US) 1992-01-02 — — EP disclosed
WO-1991000727-A1 SUBSTITUTED 2-AMINOTETRALINS WHITBY RESEARCH, INC. (US) 1991-01-24 — — WO disclosed
US-4410519-A 2-AMINO-5-HYDROXY DERIVATIVES SANDOZ LTD. (CH) 1983-10-18 — — US disclosed
US-4410519-A 2-AMINO-5-HYDROXY DERIVATIVES SANDOZ LTD. (CH) 1983-10-18 — — US disclosed
EP-0026848-B1 DERIVATIVES OF TETRALINE, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS SANDOZ AG (CH) 1983-05-04 — — EP disclosed
EP-0026848-A1 Derivatives of tetraline, their preparation and medicaments containing these compounds SANDOZ AG (CH) 1981-04-15 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10683283-B2 Substituted ureas and methods of making and using same UMPS, METTL3, UTS2R DRD2 3348/4885DRD3 2618/4885PLAU 207/4885
US-11198685-B2 Substituted ureas and methods of making and using same UMPS, METTL3, UTS2R DRD2 3348/4885DRD3 2618/4885PLAU 207/4885
US-20200308155-A1 Substituted Ureas and Methods of Making and Using Same UMPS, METTL3, UTS2R DRD2 3348/4885DRD3 2618/4885PLAU 207/4885
US-20170305877-A1 Processes for the Preparation of Rotigotine and Intermediates Thereof C1S, C1R, C3AR1 DRD2 119/4885DRD3 105/4885PLAU 2669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.