Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246857 | 0.69 | GAA (0.46) | GAAMAPTLIPGGPR84 | |
| SCHEMBL11298721 | 0.68 | GAA (0.44) | GAAMAPT | |
| SCHEMBL88563 | 0.67 | LIPG (0.50) | THRATHRBLIPG | |
| Ammonia Solution, Strong SCHEMBL28810899 | 0.66 | LIPG (0.49) | THRATHRBLIPG | |
| SCHEMBL4787984 | 0.66 | LIPG (0.53) | THRATHRBLIPG | |
| SCHEMBL27462871 | 0.66 | LIPG (0.53) | THRATHRBLIPG | |
| Iminostilbene SCHEMBL75288 | 0.65 | MAPT (1.00) | GAAMAPTTHRB | |
| Iminostilbene SCHEMBL29926907 | 0.65 | MAPT (1.00) | GAAMAPTTHRB | |
| SCHEMBL5181489 | 0.64 | LIPG (0.51) | THRATHRBLIPG | |
| SCHEMBL9870733 | 0.64 | MAPT (0.61) | GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734398-B1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2002-02-27 | — | — | EP | disclosed |
| US-5773512-A | Compounds and methods | SMITHKLINE BEECHAM CORP. (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0734398-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 1997-04-16 | — | — | EP | disclosed |
| EP-0734398-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995016712-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-06-22 | — | — | WO | disclosed |