Sugi Predict

Sugi Predict / Compounds / SCHEMBL7555029

SCHEMBL7555029

SCHEMBL7555029

COC(=O)c1ccc(Cl)c(Cl)c1N

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 1/20 0.54
▸ GAA P10253 6/20 0.47
▸ KDM4E B2RXH2 6/20 0.47
▸ ALDH1A1 P00352 4/20 0.47
▸ HSD17B10 Q99714 3/20 0.47
▸ GLA P06280 3/20 0.47
▸ MAPT P10636 2/20 0.47
▸ HPGD P15428 2/20 0.47
▸ CASP1 P29466 1/20 0.47
▸ CASP7 P55210 1/20 0.47
▸ ATM Q13315 1/20 0.47
▸ CFTR P13569 2/20 0.47
▸ NQO2 P16083 4/20 0.43
▸ PTGS2 P35354 1/20 0.43
▸ MEN1 O00255 1/20 0.42
▸ LMNA P02545 1/20 0.42
▸ KMT2A Q03164 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ CA12 O43570 1/20 0.42
▸ CA1 P00915 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29699133 0.85 ABL1 (0.54) ABL1GAAKDM4EALDH1A1HSD17B10
SCHEMBL6332541 0.85 ABL1 (0.54) ABL1GAAKDM4EALDH1A1HSD17B10
SCHEMBL2264277 0.84 ABL1 (0.53) ABL1GAAKDM4EALDH1A1HSD17B10
SCHEMBL27362505 0.82 ABL1 (0.50) ABL1GAAKDM4EALDH1A1HSD17B10
SCHEMBL11024303 0.82 ABL1 (0.51) ABL1GAAKDM4EALDH1A1HSD17B10
SCHEMBL24558234 0.82 ABL1 (0.51) ABL1GAAKDM4EALDH1A1HSD17B10
SCHEMBL30111088 0.82 ABL1 (0.51) ABL1GAAKDM4EALDH1A1HSD17B10
SCHEMBL314560 0.82 GAA (0.53) ABL1GAAKDM4EALDH1A1HSD17B10
SCHEMBL28415472 0.82 ALDH1A1 (0.59) ABL1GAAKDM4EALDH1A1HSD17B10
SCHEMBL2961456 0.80 ABL1 (0.53) ABL1GAAKDM4EALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111699176-B Quinazolinones as PARP14 inhibitors 里邦医疗公司 2025-02-14 — — CN disclosed
US-11958837-B2 Quinazolinones as PARP14 inhibitors RIBON THERAPEUTICS, INC. (US) 2024-04-16 — — US disclosed
EP-4212515-A1 QUINAZOLINONES AS PARP14 INHIBITORS Ribon Therapeutics Inc. (US) 2023-07-19 — — EP disclosed
EP-3728207-B1 QUINAZOLINONES AS PARP14 INHIBITORS RIBON THERAPEUTICS INC (US) 2023-02-01 — — EP disclosed
US-20230018702-A1 QUINAZOLINONES AS PARP14 INHIBITORS ABBVIE BIOTECHNOLOGY LTD (BM) 2023-01-19 — — US disclosed
US-11077090-B2 Compounds and compositions and uses thereof SUNOVION PHARMACEUTICALS INC. (MA) 2021-08-03 — — US disclosed
US-11077090-B2 Compounds and compositions and uses thereof SUNOVION PHARMACEUTICALS INC. (MA) 2021-08-03 — — US disclosed
US-11008308-B2 Quinazolinones as PARP14 inhibitors Ribon Therapeutics Inc. (US) 2021-05-18 — — US disclosed
EP-3728207-A1 QUINAZOLINONES AS PARP14 INHIBITORS Ribon Therapeutics Inc. (US) 2020-10-28 — — EP disclosed
CN-111699176-A Quinazolinones as PARP14 inhibitors 里邦医疗公司 2020-09-22 — — CN disclosed
US-6369270-B1 CHEMICAL INTERMEDIATES RHONE POULENC AGRICULTURE LIMITED (GB) 2002-04-09 — — US disclosed
US-6323155-B1 EXCELLENT LEVEL OF HERBICIDAL ACTIVITY TOGETHER WITH CROP TOLERANCE RHONE-POULENC AGRICULTURE LIMITED (GB) 2001-11-27 — — US disclosed
US-6114538-A 2-POSITION OF BENZOY RING OF 4-BENZOYLISOXAZOLE DERIVATIVE IS SUBSTITUTED AND PARTICULARLY USED AGAINST MONOCOTYLEDONOUS WEEDS BY POST-EMEREGENECE APPLICATION RHONE POULENC AGRICULTURE LIMITED (GB) 2000-09-05 — — US disclosed
US-5998653-A CHEMICAL INTERMEDIATE FOR HERBICIDES RHONE POULENC AGRICULTURE LIMITED (GB) 1999-12-07 — — US disclosed
EP-0674629-B1 4-BENZOYL ISOXAZOLES DERIVATIVES AND THEIR USE AS HERBICIDES RHONE POULENC AGRICULTURE (GB) 1998-07-08 — — EP disclosed
US-5658858-A POSTEMERGENCE HERBICIDES RHONE-POULENC ARGRICULTURE LIMITED (GB) 1997-08-19 — — US disclosed
EP-0734380-A1 4-BENZOYLISOXAZOLES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1996-10-02 — — EP disclosed
EP-0674629-A1 4-BENZOYL ISOXAZOLES DERIVATIVES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1995-10-04 — — EP disclosed
WO-1995016678-A1 4-BENZOYLISOXAZOLES AND THEIR USE AS HERBICIDES RHONE POULENC AGRICULTURE LIMITED (GB) 1995-06-22 — — WO disclosed
WO-1994014782-A1 4-BENZOYL ISOXAZOLES DERIVATIVES AND THEIR USE AS HERBICIDES RHONE-POULENC AGRICULTURE LTD. (GB) 1994-07-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11958837-B2 Quinazolinones as PARP14 inhibitors PARP14, PARP15, PARP11 ABL1 896/4885GAA 3263/4885KDM4E 383/4885
US-11077090-B2 Compounds and compositions and uses thereof ACHE, CHAT, MAOB ABL1 1582/4885GAA 88/4885KDM4E 3891/4885
US-11008308-B2 Quinazolinones as PARP14 inhibitors PARP14, PARP15, PARP11 ABL1 896/4885GAA 3263/4885KDM4E 383/4885
US-20230018702-A1 QUINAZOLINONES AS PARP14 INHIBITORS PARP14, PARP15, PARP11 ABL1 896/4885GAA 3263/4885KDM4E 383/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.