Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.45 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.41 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911725 | 0.78 | RAB9A (0.60) | APPALDH1A3RAB9ANPC1KDM4E | |
| SCHEMBL2735660 | 0.77 | NPC1 (0.55) | APPALDH1A3MAP3K5RAB9ANPC1 | |
| SCHEMBL3485564 | 0.75 | PIK3CG (0.60) | APPCYP11B1CYP11B2ALDH1A3MAP3K5 | |
| SCHEMBL753772 | 0.75 | PIK3CG (0.60) | APPMAP3K5CLK1DYRK1ARAB9A | |
| SCHEMBL16087132 | 0.75 | APP (0.46) | APPCYP11B1CYP11B2ALDH1A3MAP3K5 | |
| SCHEMBL12778738 | 0.75 | APP (0.46) | APPCYP11B1CYP11B2ALDH1A3MAP3K5 | |
| SCHEMBL14427902 | 0.75 | CYP11B1 (0.57) | APPCYP11B1CYP11B2ALDH1A3MAP3K5 | |
| SCHEMBL31732651 | 0.75 | APP (0.50) | APPCYP11B1CYP11B2ALDH1A3MAP3K5 | |
| SCHEMBL103426 | 0.75 | GRM5 (0.47) | APPCYP11B1CYP11B2ALDH1A3MAP3K5 | |
| SCHEMBL3340576 | 0.75 | SMN1; SMN2 (0.54) | DYRK1ARAB9ANPC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2757882-B1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2020-11-04 | — | — | EP | disclosed |
| EP-2757882-B1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME (US) | 2020-11-04 | — | — | EP | disclosed |
| US-9518055-B2 | Imidazopyridyl compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME (US) | 2016-12-13 | — | — | US | disclosed |
| US-9518055-B2 | Imidazopyridyl compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME (US) | 2016-12-13 | — | — | US | disclosed |
| US-9518055-B2 | Imidazopyridyl compounds as aldosterone synthase inhibitors | MERCK SHARP & DOHME (US) | 2016-12-13 | — | — | US | disclosed |
| US-20160031882-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME LLC | 2016-02-04 | — | — | US | disclosed |
| US-20160031882-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME LLC | 2016-02-04 | — | — | US | disclosed |
| US-20160031882-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME LLC | 2016-02-04 | — | — | US | disclosed |
| US-9173873-B2 | — | — | 2015-11-03 | — | — | US | disclosed |
| US-9173873-B2 | — | — | 2015-11-03 | — | — | US | disclosed |
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | disclosed |
| US-20140235667-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2014-08-21 | — | — | US | disclosed |
| US-20140235667-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2014-08-21 | — | — | US | disclosed |
| US-20140235667-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2014-08-21 | — | — | US | disclosed |
| EP-2757882-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-07-30 | — | — | EP | disclosed |
| WO-2013043518-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-03-28 | — | — | WO | disclosed |
| WO-2013043518-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-03-28 | — | — | WO | disclosed |
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | AMGEN INC. (US) | 2012-07-26 | — | — | US | disclosed |
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235667-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | NR3C2, CYP21A2, HSD11B1 | APP 3230/4885CYP11B1 4/4885CYP11B2 6/4885 |
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | PIK3CA, PIKFYVE, PIK3CD | APP 4224/4885CYP11B1 1090/4885CYP11B2 1479/4885 |
| US-20160031882-A1 | IMIDAZOPYRIDYL COMPOUNDS AS ALDOSTERONE SYNTHASE INHIBITORS | NR3C2, CYP21A2, HSD11B1 | APP 3271/4885CYP11B1 4/4885CYP11B2 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.