Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.40 |
| ▸ | JAK3 | P52333 | 9/20 | 0.40 |
| ▸ | JAK1 | P23458 | 8/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | EEF2K | O00418 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383138 | 0.74 | PARP1 (0.40) | JAK2JAK3JAK1TYK2ALDH1A1 | |
| SCHEMBL16787434 | 0.70 | DAO (0.57) | JAK2JAK3JAK1DRD2 | |
| SCHEMBL16819110 | 0.68 | JAK2 (0.41) | JAK2JAK3JAK1DRD2 | |
| SCHEMBL28511270 | 0.67 | JAK2 (0.42) | JAK2JAK3ALDH1A1BRD4ATAD2 | |
| SCHEMBL6690208 | 0.67 | JAK2 (0.44) | JAK2JAK3JAK1TYK2DRD1 | |
| SCHEMBL15552906 | 0.66 | JAK2 (0.48) | JAK2JAK3JAK1PIK3CAMTOR | |
| SCHEMBL1380290 | 0.66 | EEF2K (0.39) | JAK2JAK3JAK1TYK2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7559739 | 0.65 | TNKS (0.38) | JAK2JAK3JAK1TYK2DRD1 | |
| SCHEMBL9842532 | 0.65 | CYP3A4 (0.62) | JAK2JAK3JAK1ALDH1A1POLB | |
| SCHEMBL3632106 | 0.63 | DAO (0.51) | JAK2JAK3BRD4PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255739-A1 | 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001053273-A1 | 3-AMINOQUINAZOLIN-2,4-DIONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2001-07-26 | — | — | WO | disclosed |