Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5398913 | 0.92 | P2RX7 (0.63) | P2RX7HRH3UTS2RALDH1A1SMN1; SMN2 | |
| SCHEMBL7555599 | 0.83 | HRH3 (0.42) | P2RX7HRH3NPC1RAB9APOLB | |
| SCHEMBL7515669 | 0.79 | P2RX7 (0.48) | P2RX7HRH3SMN1; SMN2HRH1CCR3 | |
| SCHEMBL7556141 | 0.77 | P2RX7 (0.85) | P2RX7 | |
| SCHEMBL7554565 | 0.76 | P2RX7 (0.51) | P2RX7NPC1RAB9APOLBHPGD | |
| SCHEMBL7518675 | 0.75 | ESRRB (0.49) | P2RX7NPC1RAB9APOLBHPGD | |
| SCHEMBL7555457 | 0.75 | P2RX7 (0.47) | P2RX7 | |
| SCHEMBL7559238 | 0.74 | HPGD (0.46) | P2RX7NPC1RAB9APOLBHPGD | |
| SCHEMBL7603269 | 0.73 | P2RX7 (0.45) | P2RX7HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL21434774 | 0.72 | KDM4E (0.55) | P2RX7HRH3NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492355-B1 | Adamantane derivatives | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1171432-A1 | ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061569-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-10-19 | — | — | WO | disclosed |