Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | TNK1 | Q13470 | 3/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7559952 | 0.91 | P2RX7 (0.61) | P2RX7ADRB1CHRM3MEN1KMT2A | |
| SCHEMBL7553515 | 0.88 | P2RX7 (0.58) | P2RX7ADRB1CHRM3MEN1KMT2A | |
| SCHEMBL29115477 | 0.80 | ADRB1 (0.56) | P2RX7ADRB1POLBPARP1TNK1 | |
| SCHEMBL7559466 | 0.78 | DRD3 (0.46) | P2RX7ADRB1CHRM3KMT2AHTR1A | |
| SCHEMBL7518675 | 0.77 | ESRRB (0.49) | P2RX7POLBHPGDTP53THRB | |
| SCHEMBL7554812 | 0.77 | P2RX7 (0.45) | P2RX7POLBHPGDMEN1KMT2A | |
| SCHEMBL3951445 | 0.77 | P2RX7 (0.64) | P2RX7CHRM3 | |
| SCHEMBL7660582 | 0.76 | P2RX7 (0.84) | P2RX7 | |
| SCHEMBL7556147 | 0.76 | P2RX7 (0.52) | P2RX7POLBHPGDSLC6A4NPC1 | |
| SCHEMBL7559238 | 0.76 | HPGD (0.46) | P2RX7POLBHPGDKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171432-A1 | ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000061569-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-10-19 | — | — | WO | disclosed |