Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7554835 | 0.96 | L3MBTL3 (0.41) | L3MBTL3L3MBTL1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7521540 | 0.82 | L3MBTL3 (0.39) | L3MBTL3L3MBTL1SHMT2CYP3A4CYP2D6 | |
| SCHEMBL7510780 | 0.79 | L3MBTL3 (0.37) | L3MBTL3L3MBTL1SHMT2CYP3A4CYP2D6 | |
| SCHEMBL7510801 | 0.76 | MAPT (0.41) | L3MBTL3L3MBTL1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL29795175 | 0.76 | HDAC6 (0.52) | L3MBTL3L3MBTL1 | |
| SCHEMBL22943880 | 0.76 | HDAC6 (0.52) | L3MBTL3L3MBTL1 | |
| SCHEMBL22943890 | 0.76 | HDAC6 (0.52) | L3MBTL3L3MBTL1 | |
| SCHEMBL29795212 | 0.76 | HDAC6 (0.52) | L3MBTL3L3MBTL1 | |
| SCHEMBL7512820 | 0.75 | MAPT (0.41) | L3MBTL1CYP3A4CYP2D6CYP2C19TP53 | |
| Hydrochloric Acid SCHEMBL7512210 | 0.75 | MAPT (0.41) | L3MBTL3L3MBTL1TP53SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | claimed |
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| US-6140322-A | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase | ASTRA AKTIEBOLAG (SE) | 2000-10-31 | — | — | US | disclosed |