Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7520313 | 0.99 | MAPT (0.40) | MAPTRAB9ALMNANPC1NFKB1 | |
| SCHEMBL7510801 | 0.99 | MAPT (0.41) | MAPTRAB9ALMNANPC1NFKB1 | |
| Hydrochloric Acid SCHEMBL7512210 | 0.98 | MAPT (0.41) | MAPTRAB9ALMNANPC1NFKB1 | |
| SCHEMBL7513058 | 0.96 | RAB9A (0.42) | MAPTRAB9ALMNANPC1NFKB1 | |
| SCHEMBL7511381 | 0.83 | ALDH1A1 (0.39) | MAPTRAB9ALMNANPC1NFKB1 | |
| SCHEMBL7509837 | 0.82 | NOS1 (0.39) | MAPTRAB9ALMNANPC1NFKB1 | |
| SCHEMBL7510035 | 0.82 | NPC1 (0.41) | MAPTRAB9ALMNANPC1NFKB1 | |
| Hydrochloric Acid SCHEMBL7514108 | 0.82 | ALDH1A1 (0.39) | MAPTRAB9ALMNANPC1NFKB1 | |
| SCHEMBL7509087 | 0.80 | MAPT (0.43) | MAPTRAB9ALMNANPC1NFKB1 | |
| SCHEMBL7506634 | 0.80 | ALDH1A1 (0.40) | MAPTRAB9ALMNANPC1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861250-B1 | AMIDINE AND ISOTHIOUREA DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-02-13 | — | — | EP | claimed |