Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6074662 | 0.83 | CHRNB2 (0.46) | CHRNB2CHRNA4ADRB2ADRB1ADRB3 | |
| SCHEMBL27580967 | 0.83 | CHRNB2 (0.46) | CHRNB2CHRNA4ADRB2ADRB1ADRB3 | |
| SCHEMBL30566059 | 0.83 | LMNA (0.61) | CHRNB2CHRNA4LMNA | |
| SCHEMBL27575925 | 0.83 | LMNA (0.61) | CHRNB2CHRNA4LMNA | |
| SCHEMBL27742506 | 0.80 | CHRNB2 (0.50) | CHRNB2CHRNA4 | |
| SCHEMBL27674373 | 0.80 | CHRNB2 (0.50) | CHRNB2CHRNA4 | |
| SCHEMBL11515571 | 0.80 | CHRNB2 (0.43) | CHRNB2CHRNA4ADRB2ADRB1ADRB3 | |
| SCHEMBL11730639 | 0.80 | CHRNB2 (0.43) | CHRNB2CHRNA4ADRB2ADRB1ADRB3 | |
| SCHEMBL2608833 | 0.79 | CHRNB2 (0.58) | CHRNB2CHRNA4 | |
| SCHEMBL17372541 | 0.79 | CHRNB2 (0.51) | CHRNB2CHRNA4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171127-A2 | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDINE OR PYRIMIDINE DERIVATIVES FOR INHIBITION OF CYTOKINE PRODUCTION AND SECRETION | Targacept, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000062767-A2 | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDINE OR PYRIMIDINE DERIVATES FOR INHIBITION OF CYTOKINE PRODUCTION AND SECRETION | TARGACEPT, INC. (US) | 2000-10-26 | — | — | WO | disclosed |