Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | FURIN | P09958 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31010846 | 1.00 | MTOR (0.50) | MTORHDAC1HDAC2GRM5FURIN | |
| SCHEMBL1926964 | 0.86 | MTOR (0.52) | MTORHDAC1HDAC2GRM5FURIN | |
| SCHEMBL4680426 | 0.80 | FURIN (0.44) | GRM5FURINALDH1A1PLK4CHEK1 | |
| SCHEMBL2290042 | 0.78 | HDAC8 (0.63) | MTORHDAC1HDAC2GRM5F2 | |
| SCHEMBL2293623 | 0.78 | ALDH1A1 (0.63) | MTORHDAC1HDAC2GRM5F2 | |
| SCHEMBL31215053 | 0.78 | TPMT (0.45) | HDAC1F2ALDH1A1PLAUCYP1A2 | |
| Hydrochloric Acid SCHEMBL8443994 | 0.78 | PLK4 (0.49) | FURINALDH1A1PLK4CHEK1AURKA | |
| Hydrochloric Acid SCHEMBL8504624 | 0.78 | PARP1 (0.58) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5175529 | 0.78 | HDAC8 (0.62) | HDAC1GRM5KAT6AALDH1A1HDAC8 | |
| Ammonia Solution, Strong SCHEMBL29199663 | 0.77 | PARP1 (0.57) | MTORHDAC1HDAC2GRM5F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185316-A1 | DEVICES AND COMPOUNDS FOR TREATING ARTERIAL RESTENOSIS | Cardio Vascular Solutions Inc. (CA) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000074742-A1 | DEVICES AND COMPOUNDS FOR TREATING ARTERIAL RESTENOSIS | CARDIO VASCULAR SOLUTIONS INC. (CA) | 2000-12-14 | — | — | WO | disclosed |