Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | NSD2 | O96028 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | EHMT2 | Q96KQ7 | 5/20 | 0.53 |
| ▸ | TOP1 | P11387 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29587040 | 1.00 | MALT1 (0.62) | MALT1MEN1POLBBLMKMT2A | |
| SCHEMBL31218590 | 1.00 | MALT1 (0.62) | MALT1MEN1POLBBLMKMT2A | |
| SCHEMBL19743776 | 0.91 | MALT1 (0.54) | MALT1MEN1POLBBLMKMT2A | |
| SCHEMBL31218592 | 0.91 | SMN1; SMN2 (0.62) | MALT1MEN1POLBBLMKMT2A | |
| SCHEMBL6671719 | 0.91 | MALT1 (0.54) | MALT1MEN1POLBBLMKMT2A | |
| SCHEMBL18984755 | 0.90 | SMN1; SMN2 (0.67) | MALT1MEN1POLBBLMKMT2A | |
| SCHEMBL30818304 | 0.90 | SMN1; SMN2 (0.67) | MALT1MEN1POLBBLMKMT2A | |
| SCHEMBL10399866 | 0.90 | SMN1; SMN2 (0.54) | MALT1MEN1POLBBLMKMT2A | |
| SCHEMBL3418752 | 0.89 | MAPT (0.63) | MALT1MEN1POLBBLMKMT2A | |
| SCHEMBL31218585 | 0.89 | MAPT (0.63) | MALT1MEN1POLBBLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225169-A1 | Radiation-activated cytotoxin therapy | AUCKLAND UNISERVICES LIMITED (NZ) | 2002-07-24 | — | — | EP | disclosed |
| US-6071908-A | A RADIATION-ACTIVATED CYTOTOXIN PRODRUG HAVING LOW TOXICITY, WHICH CAN BE REDUCED BY REDUCING AGENTS GENERATED BY THE RADIOLYSIS OF WATER WHICH RELEASES AN CYTOXIC EFFECTOR; ANTITUMOR,-CARCINOGENIC AGENTS; | AUCKLAND UNISERVICES LIMITED (NZ) | 2000-06-06 | — | — | US | disclosed |
| US-4540583-A | 1,4-BIS/AMINOETHYL-ANTHRAQUINONES | AMERICAN CYANAMID COMPANY (US) | 1985-09-10 | — | — | US | disclosed |