Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7722529 | 0.92 | HDAC4 (0.46) | HDAC4MEN1KMT2APGRHTR1A | |
| SCHEMBL7201251 | 0.86 | HDAC4 (0.48) | HDAC4MEN1KMT2APGRHTR1A | |
| SCHEMBL5164306 | 0.85 | HDAC4 (0.48) | HDAC4MEN1KMT2APGRHTR1A | |
| SCHEMBL5163897 | 0.84 | HDAC4 (0.64) | HDAC4MEN1KMT2APGRHIF1A | |
| SCHEMBL7614121 | 0.83 | HDAC4 (0.46) | HDAC4MEN1KMT2APGRHTR1A | |
| SCHEMBL7722661 | 0.83 | HDAC4 (0.46) | HDAC4MEN1KMT2APGRHTR1A | |
| SCHEMBL8151208 | 0.82 | HDAC4 (0.38) | HDAC4MEN1KMT2APGRCRHBP | |
| SCHEMBL7862440 | 0.81 | KMT2A (0.64) | HDAC4MEN1KMT2APGRNPC1 | |
| SCHEMBL7558495 | 0.80 | HDAC4 (0.53) | HDAC4MEN1KMT2APGRALDH1A1 | |
| SCHEMBL7558383 | 0.78 | HDAC4 (0.71) | HDAC4MEN1KMT2APGRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121287-A | Quinoline derivatives | ACTIVE BIOTECH AB (SE) | 2000-09-19 | — | — | US | claimed |
| EP-1224172-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | Active Biotech AB (SE) | 2002-07-24 | — | — | EP | disclosed |
| US-6395750-B1 | Includes laquinimod, N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxamide and its salts; breat or prostate cancer | ACTIVE BIOTECH AB (SE) | 2002-05-28 | — | — | US | disclosed |
| WO-2001030758-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2001-05-03 | — | — | WO | disclosed |
| US-6121287-A | Quinoline derivatives | ACTIVE BIOTECH AB (SE) | 2000-09-19 | — | — | US | disclosed |