Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900804 | 1.00 | L3MBTL1 (0.50) | L3MBTL1SSTR4TSHRMAPK1ALDH1A1 | |
| SCHEMBL3652033 | 1.00 | L3MBTL1 (0.50) | L3MBTL1SSTR4TSHRMAPK1ALDH1A1 | |
| SCHEMBL18823908 | 0.86 | L3MBTL1 (0.62) | L3MBTL1SSTR4TSHRMAPK1ALDH1A1 | |
| SCHEMBL30049017 | 0.83 | L3MBTL1 (0.37) | L3MBTL1SSTR4ADRA1DADRA1AADRA1B | |
| SCHEMBL26501818 | 0.82 | L3MBTL1 (0.54) | L3MBTL1TSHRMAPK1ALDH1A1ADRA1D | |
| SCHEMBL15373851 | 0.82 | L3MBTL1 (0.54) | L3MBTL1TSHRMAPK1ALDH1A1ADRA1D | |
| SCHEMBL1993835 | 0.80 | CHRNB2 (0.47) | L3MBTL1CHRNB2CHRNA7CHRNA4PRCP | |
| SCHEMBL1991927 | 0.80 | CHRNB2 (0.47) | L3MBTL1CHRNB2CHRNA7CHRNA4PRCP | |
| SCHEMBL2415851 | 0.80 | CHRNB2 (0.47) | L3MBTL1CHRNB2CHRNA7CHRNA4PRCP | |
| SCHEMBL5892835 | 0.78 | HDAC8 (0.32) | CHRNB2CHRNA7CHRNA4HDAC8PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705824-B1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE N-TERT-BUTYL- 2-PIPERAZINE- CARBOXAMIDE | KOEI CHEMICAL CO (JP) | 2002-08-07 | — | — | EP | claimed |
| US-5792869-A | REACTING PIPERAZINE DERIVATIVE WITH SULFONAMIDE DERIVATIVE OF OPTICALLY ACTIVE AMINO ACID, PRECIPITATING LESS SOLUBLE SALT, SEPARATING, DECOMPOSING TO DESIRED DIASTEREOMER | YAMAKAWA CHEMICAL INDUSTRY CO., LTD (JP) | 1998-08-11 | — | — | US | claimed |
| EP-0705824-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE N-TERT-BUTYL-2-PIPERAZINECARBOXAMIDE AND METHOD OF RACEMIZING THE AMIDE | KOEI CHEMICAL CO., LTD. (JP) | 1996-04-10 | — | — | EP | claimed |
| JP-11228546-A | — | — | None | — | — | JP | disclosed |
| JP-10087636-A | — | — | None | — | — | JP | disclosed |
| EP-0705824-B1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE N-TERT-BUTYL- 2-PIPERAZINE- CARBOXAMIDE | KOEI CHEMICAL CO (JP) | 2002-08-07 | — | — | EP | disclosed |
| EP-0705824-B1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE N-TERT-BUTYL- 2-PIPERAZINE- CARBOXAMIDE | KOEI CHEMICAL CO (JP) | 2002-08-07 | — | — | EP | disclosed |
| JP-H11228546-A | PRODUCTION OF OPTICALLY ACTIVE 2-(N-TERT-BUTYLCARBAMOYL) PIPERAZINE | KOEI CHEM CO LTD | 1999-08-24 | — | — | JP | disclosed |
| US-5792869-A | REACTING PIPERAZINE DERIVATIVE WITH SULFONAMIDE DERIVATIVE OF OPTICALLY ACTIVE AMINO ACID, PRECIPITATING LESS SOLUBLE SALT, SEPARATING, DECOMPOSING TO DESIRED DIASTEREOMER | YAMAKAWA CHEMICAL INDUSTRY CO., LTD (JP) | 1998-08-11 | — | — | US | disclosed |
| JP-H1087636-A | PRODUCTION OF OPTICALLY ACTIVE N-T-BUTYL-2-PIPERAZINAMIDE | TOSOH CORP | 1998-04-07 | — | — | JP | disclosed |
| EP-0710652-B1 | Process for preparing optically active piperazine derivatives and intermediates for preparation | YAMAKAWA CHEMICAL IND (JP) | 1998-03-04 | — | — | EP | disclosed |
| EP-0705824-A4 | PROCESS FOR PRODUCING OPTICALLY ACTIVE N-TERT-BUTYL-2-PIPERAZINECARBOXAMIDE AND METHOD OF RACEMIZING THE AMIDE | KOEI CHEMICAL CO (JP) | 1996-08-14 | — | — | EP | disclosed |
| EP-0710652-A2 | Process for preparing optically active piperazine derivatives and intermediates for preparation | YAMAKAWA CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-05-08 | — | — | EP | disclosed |
| EP-0705824-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE N-TERT-BUTYL-2-PIPERAZINECARBOXAMIDE AND METHOD OF RACEMIZING THE AMIDE | KOEI CHEMICAL CO., LTD. (JP) | 1996-04-10 | — | — | EP | disclosed |
| EP-0705824-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE N-TERT-BUTYL-2-PIPERAZINECARBOXAMIDE AND METHOD OF RACEMIZING THE AMIDE | KOEI CHEMICAL CO., LTD. (JP) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995029170-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE N-TERT-BUTYL-2-PIPERAZINECARBOXAMIDE AND METHOD OF RACEMIZING THE AMIDE | KOEI CHEMICAL CO., LTD. (JP) | 1995-11-02 | — | — | WO | disclosed |