Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 5/20 | 0.66 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.66 |
| ▸ | TOP2A | P11388 | 3/20 | 0.66 |
| ▸ | GLA | P06280 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | CASP1 | P29466 | 2/20 | 0.66 |
| ▸ | CASP7 | P55210 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | TOP1 | P11387 | 1/20 | 0.66 |
| ▸ | DRD2 | P14416 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.66 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL22716096 | 0.99 | KMT2A (0.67) | KDM1ATOP2BTOP2AGLACYP1A2 | |
| SCHEMBL31238359 | 0.81 | KDM1A (0.74) | KDM1ATOP2BTOP2AGLACYP1A2 | |
| SCHEMBL10416620 | 0.80 | GAA (0.59) | PTGS2HSD17B10KMT2AMEN1GFER | |
| Amsacrine SCHEMBL29350869 | 0.80 | TOP2B (1.00) | KDM1ATOP2BTOP2AGLACYP1A2 | |
| O-Amsacrine SCHEMBL30941682 | 0.80 | TOP2B (0.83) | KDM1ATOP2BTOP2AGLACYP1A2 | |
| Amsacrine SCHEMBL28336991 | 0.80 | TOP2B (1.00) | KDM1ATOP2BTOP2AGLACYP1A2 | |
| Amsacrine SCHEMBL4047 | 0.80 | TOP2B (1.00) | KDM1ATOP2BTOP2AGLACYP1A2 | |
| Amsacrine SCHEMBL6256280 | 0.80 | TOP2B (1.00) | KDM1ATOP2BTOP2AGLACYP1A2 | |
| Amsacrine SCHEMBL29360354 | 0.80 | TOP2B (1.00) | KDM1ATOP2BTOP2AGLACYP1A2 | |
| Amsacrine SCHEMBL31316257 | 0.79 | KMT2A (1.00) | KDM1ATOP2BTOP2AGLACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224322-A2 | GENE SEQUENCE VARIATIONS WITH UTILITY IN DETERMINING THE TREATMENT OF DISEASE | Variagenics, Inc. (US) | 2002-07-24 | — | — | EP | disclosed |
| EP-1087801-B1 | TOPOISOMERASE INHIBITORS FOR PREVENTION OF RESTENOSIS | QUANAM MEDICAL CORP (US) | 2002-01-16 | — | — | EP | disclosed |
| US-20020004679-A1 | Topoisomerase inhibitors for prevention of restenosis | QUANAM MEDICAL CORPORATION | 2002-01-10 | — | — | US | disclosed |
| EP-1087801-A1 | TOPOISOMERASE INHIBITORS FOR PREVENTION OF RESTENOSIS | Quanam Medical Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-2000050639-A2 | GENE SEQUENCE VARIATIONS WITH UTILITY IN DETERMINING THE TREATMENT OF DISEASE | VARIAGENICS, INC. (US) | 2000-08-31 | — | — | WO | disclosed |
| WO-2000000238-A9 | TOPOISOMERASE INHIBITORS FOR PREVENTION OF RESTENOSIS | QUANAM MEDICAL CORP (US) | 2000-05-11 | — | — | WO | disclosed |
| WO-2000000238-A1 | TOPOISOMERASE INHIBITORS FOR PREVENTION OF RESTENOSIS | QUANAM MEDICAL CORPORATION (US) | 2000-01-06 | — | — | WO | disclosed |