Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7061990 | 1.00 | CHRNB2 (0.41) | CHRNB2CHRNA7CHRNA4NPC1RAB9A | |
| SCHEMBL7060716 | 0.91 | PDE4B (0.47) | PDE4BPDE4DACKR3SLC9A1GAA | |
| SCHEMBL7058005 | 0.89 | CHRNA7 (0.42) | CHRNB2CHRNA7CHRNA4NPC1RAB9A | |
| SCHEMBL7062872 | 0.88 | CHRNB2 (0.44) | CHRNB2CHRNA7CHRNA4NPC1RAB9A | |
| SCHEMBL7062286 | 0.88 | CHRNB2 (0.42) | CHRNB2CHRNA7CHRNA4S1PR4MEN1 | |
| SCHEMBL7063432 | 0.87 | RAB9A (0.52) | CHRNB2CHRNA7CHRNA4NPC1RAB9A | |
| SCHEMBL7063371 | 0.85 | S1PR2 (0.50) | CHRNB2CHRNA7CHRNA4NPC1RAB9A | |
| SCHEMBL7061493 | 0.85 | PDE7A (0.50) | CHRNB2CHRNA7CHRNA4NPC1RAB9A | |
| SCHEMBL7063300 | 0.83 | CHRNB2 (0.50) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL7057847 | 0.83 | CHRNB2 (0.51) | CHRNB2CHRNA7CHRNA4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002015662-A2 | QUINUCLIDINE-SUBSTITUTED HETEROARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | disclosed |