Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 13/20 | 0.49 |
| ▸ | RARB | P10826 | 11/20 | 0.49 |
| ▸ | RARG | P13631 | 11/20 | 0.49 |
| ▸ | RXRB | P28702 | 9/20 | 0.49 |
| ▸ | RXRG | P48443 | 7/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.46 |
| ▸ | RARA | P10276 | 8/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15617210 | 0.75 | RXRA (0.56) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7565233 | 0.74 | RXRA (0.46) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL17914352 | 0.73 | RXRA (0.54) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL6528854 | 0.72 | RXRA (0.53) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL20277839 | 0.72 | RXRA (0.53) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7560489 | 0.69 | RXRA (0.50) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7759680 | 0.68 | RXRA (0.69) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL1022234 | 0.66 | RXRA (0.63) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7723487 | 0.66 | RXRA (1.00) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL6473308 | 0.66 | CYP26B1 (0.47) | RXRARARBRARGRXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986537-B1 | NOVEL HETEROETHYNYLENE COMPOUNDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | GALDERMA RES & DEV (FR) | 2002-08-07 | — | — | EP | disclosed |
| EP-0986537-A2 | NOVEL HETEROETHYNYLENE COMPOUNDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | Galderma Research & Development, S.N.C. (FR) | 2000-03-22 | — | — | EP | disclosed |
| WO-1999050239-A2 | NOVEL HETEROETHYNYLENE COMPOUNDS AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 1999-10-07 | — | — | WO | disclosed |