Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 6/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7568295 | 0.77 | PTGS2 (0.41) | PTGS1PTGS2ALOX5 | |
| SCHEMBL25181143 | 0.74 | PTGS2 (0.36) | PTGS1PTGS2ALOX5NOTUM | |
| SCHEMBL7564517 | 0.72 | PTGS2 (0.41) | PTGS1PTGS2ALOX5 | |
| SCHEMBL7563291 | 0.72 | PTGS2 (0.38) | PTGS1PTGS2ALOX5 | |
| SCHEMBL2489432 | 0.72 | AHR (0.38) | PTGS1PTGS2ALOX5NOTUM | |
| SCHEMBL6756512 | 0.70 | GABRA1 (0.41) | PTGS1PTGS2ALOX5NOTUM | |
| SCHEMBL5659858 | 0.70 | PTGS2 (0.36) | PTGS1PTGS2ALOX5 | |
| SCHEMBL7564521 | 0.70 | PTGS2 (0.34) | PTGS1PTGS2ALOX5NOTUM | |
| SCHEMBL7564258 | 0.69 | AKR1C3 (0.38) | — | |
| SCHEMBL3478661 | 0.69 | PTGS2 (0.34) | PTGS1PTGS2ALOX5NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228055-A1 | DIHYDROAMINOBENZO[B]- AND [C]FURANS AS RETINOID-LIKE AGENTS | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012618-A1 | DIHYDROAMINOBENZO[B]- AND [C]FURANS AS RETINOID-LIKE AGENTS | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6093838-A | FOR TREATING SKIN-RELATED DISEASES, INCLUDING ACTINIC KERATOSES, ARSENIC KERATOSES, ECZEMA | ALLERGAN SALES, INC. (US) | 2000-07-25 | — | — | US | disclosed |