SCHEMBL7562619

SCHEMBL7562619

CC(C)COC(=O)C1(OCC(C)C)C=Cc2ccccc2N1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX4 Q99571 2/20 0.41
ALDH1A1 P00352 7/20 0.39
TSHR P16473 1/20 0.39
KDM4E B2RXH2 4/20 0.34
GAA P10253 1/20 0.34
ELANE P08246 1/20 0.34
CACNA1F O60840 1/20 0.34
CACNA1D Q01668 1/20 0.34
CACNA1S Q13698 1/20 0.34
CACNA1C Q13936 1/20 0.34
SMN1; SMN2 Q16637 4/20 0.33
MAPT P10636 3/20 0.33
PLA2G1B P04054 1/20 0.33
ATG4B Q9Y4P1 1/20 0.33
ADORA2B P29275 1/20 0.31
HSD17B10 Q99714 2/20 0.31
HPGD P15428 2/20 0.31
ALOX15 P16050 1/20 0.31
RAB9A P51151 2/20 0.31
NPC1 O15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30250427 0.81 BRD4 (0.40) ALDH1A1TSHRKDM4EGAASMN1; SMN2
SCHEMBL6991005 0.81 BRD4 (0.40) ALDH1A1TSHRKDM4EGAASMN1; SMN2
SCHEMBL31305217 0.73 MAPT (0.35) ALDH1A1TSHRKDM4EGAASMN1; SMN2
SCHEMBL10980767 0.64 ALDH1A1 (0.38) P2RX4ALDH1A1KDM4EGAASMN1; SMN2
SCHEMBL29975999 0.64 GAA (0.39) P2RX4ALDH1A1KDM4EGAAMAPT
SCHEMBL28544078 0.64 GAA (0.39) P2RX4ALDH1A1KDM4EGAAMAPT
SCHEMBL4611922 0.63 P2RX4 (0.40) P2RX4ALDH1A1TSHRELANECACNA1F
SCHEMBL6097775 0.63 ALDH1A1 (0.41) P2RX4ALDH1A1TSHRKDM4EGAA
SCHEMBL31448339 0.61 MAPT (0.43) P2RX4ALDH1A1KDM4EGAASMN1; SMN2
SCHEMBL28059865 0.61 MAPT (0.43) P2RX4ALDH1A1KDM4EGAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0830353-B1 PROCESS FOR THE PREPARATION OF AN HIV PROTEASE INHIBITING COMPOUND ABBOTT LAB (US) 2002-04-24 EP disclosed
EP-0830353-A1 PROCESS FOR THE PREPARATION OF AN HIV PROTEASE INHIBITING COMPOUND Abbott Laboratories (US) 1998-03-25 EP disclosed
WO-1996039398-A1 PROCESS FOR THE PREPARATION OF AN HIV PROTEASE INHIBITING COMPOUND ABBOTT LABORATORIES (US) 1996-12-12 WO disclosed
US-5567823-A Process for the preparation of an HIV protease inhibiting compound ABBOTT LABORATORIES (US) 1996-10-22 US disclosed