Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7729896 | 0.78 | IDO1 (0.44) | IDO1LOXL2ALDH1A1TSHRCYP2C19 | |
| SCHEMBL28524238 | 0.78 | AKR1C3 (0.46) | IDO1LOXL2ALDH1A1TSHRCYP2C19 | |
| SCHEMBL14010380 | 0.74 | LOXL2 (0.53) | IDO1LOXL2ALDH1A1TSHRCYP2C19 | |
| SCHEMBL13541455 | 0.73 | TSHR (0.50) | IDO1LOXL2ALDH1A1TSHRCYP2C19 | |
| SCHEMBL27594776 | 0.73 | ALDH1A1 (0.42) | IDO1ALDH1A1TSHRCYP1A2LMNA | |
| SCHEMBL8710389 | 0.73 | EPHX1 (0.44) | CYP1A2 | |
| SCHEMBL23111943 | 0.73 | KMT2A (0.50) | ALDH1A1CYP2C19CYP1A2AKR1C3MMP2 | |
| SCHEMBL29602251 | 0.73 | KMT2A (0.50) | ALDH1A1CYP2C19CYP1A2AKR1C3MMP2 | |
| SCHEMBL23111942 | 0.73 | KMT2A (0.50) | ALDH1A1CYP2C19CYP1A2MMP2 | |
| SCHEMBL23409273 | 0.73 | KMT2A (0.50) | ALDH1A1CYP2C19CYP1A2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0764152-B1 | SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-07-31 | — | — | EP | claimed |
| EP-0764152-B1 | SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2002-07-31 | — | — | EP | disclosed |
| EP-0853614-B1 | SUBSTITUTED TETRALYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-10-04 | — | — | EP | disclosed |
| US-6147073-A | IMPROVED BIOAVAILABILITY | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-14 | — | — | US | disclosed |
| US-5905149-A | CHEMICAL CONDENSATION OF ALDEHYDE WITH INDOLONE COMPOUND | PHARMACIA & UPJOHN S.P.A (IT) | 1999-05-18 | — | — | US | disclosed |
| US-5849710-A | Substituted indolylmethylene-oxindole analogues as tyrosine kinase inhibitors | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-12-15 | — | — | US | disclosed |
| EP-0764152-A1 | SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-03-26 | — | — | EP | disclosed |
| WO-1996032380-A1 | SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1996-10-17 | — | — | WO | disclosed |