Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8411053 | 0.86 | HSD17B10 (0.59) | ALDH1A1SMN1; SMN2HSD17B10CHRM1POLB | |
| SCHEMBL8411492 | 0.78 | FUCA1 (0.37) | ALDH1A1SMN1; SMN2HSD17B10CHRM1 | |
| SCHEMBL7839034 | 0.78 | HSD11B1 (0.40) | ALDH1A1SMN1; SMN2HSD17B10CHRM1KMT2A | |
| SCHEMBL8413126 | 0.78 | FUCA1 (0.37) | ALDH1A1SMN1; SMN2HSD17B10CHRM1 | |
| SCHEMBL8413980 | 0.77 | DPP4 (0.40) | ALDH1A1CHRM1POLBKMT2A | |
| SCHEMBL27660866 | 0.76 | EPHX1 (0.46) | ALDH1A1CYP1A2POLB | |
| SCHEMBL28026869 | 0.76 | EPHX1 (0.46) | ALDH1A1CYP1A2POLB | |
| Diphenylmethane SCHEMBL28522550 | 0.74 | LTA4H (0.64) | ALDH1A1SMN1; SMN2LTA4HHTTNPSR1 | |
| SCHEMBL6339526 | 0.74 | ERAP2 (0.48) | LTA4H | |
| SCHEMBL3137083 | 0.74 | ERAP2 (0.48) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832066-B1 | SUBSTITUTED N-(INDOLE-2-CARBONYL-) AMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER (US) | 2001-09-12 | — | — | EP | claimed |
| EP-1224179-A2 | SODIUM-HYDROGEN EXCHANGER TYPE 1 INHIBITOR CRYSTALS | Pfizer Products Inc. (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001030759-A2 | SODIUM-HYDROGEN EXCHANGER TYPE 1 INHIBITOR CRYSTALS | PFIZER PRODUCTS INC. (US) | 2001-05-03 | — | — | WO | disclosed |
| EP-1032424-A1 | COMBINATION OF AN ALDOSE REDUCTASE INHIBITOR AND A GLYCOGEN PHOSPHORYLASE INHIBITOR | Pfizer Products Inc. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999026659-A1 | COMBINATION OF AN ALDOSE REDUCTASE INHIBITOR AND A GLYCOGEN PHOSPHORYLASE INHIBITOR | PFIZER PRODUCTS INC. (US) | 1999-06-03 | — | — | WO | disclosed |