Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.32 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.32 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4525728 | 0.85 | SMN1; SMN2 (0.36) | ALDH1A1NR1H4EPHX2SMN1; SMN2FSCN1 | |
| SCHEMBL8091350 | 0.81 | APEX1 (0.47) | ALDH1A1NR1H4EPHX2SMN1; SMN2FSCN1 | |
| SCHEMBL13674398 | 0.78 | BRD4 (0.40) | ALDH1A1NR1H4RXRATP53NPY2R | |
| SCHEMBL3191479 | 0.75 | TSHR (0.50) | ALDH1A1NR1H4SMN1; SMN2CYP3A4POLB | |
| SCHEMBL8953609 | 0.74 | CA1 (0.42) | ALDH1A1NR1H4SMN1; SMN2CYP3A4POLB | |
| SCHEMBL12435790 | 0.71 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2FSCN1POLBGPBAR1 | |
| SCHEMBL11002737 | 0.71 | SMN1; SMN2 (0.35) | ALDH1A1NR1H4EPHX2PGRSMN1; SMN2 | |
| SCHEMBL11674722 | 0.70 | APEX1 (0.44) | ALDH1A1SMN1; SMN2CYP3A4APEX1RXRA | |
| SCHEMBL10918728 | 0.70 | SMN1; SMN2 (0.44) | ALDH1A1EPHX2SMN1; SMN2CYP3A4GPBAR1 | |
| SCHEMBL31167272 | 0.69 | PDCD1 (0.41) | ALDH1A1SMN1; SMN2CYP3A4POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1250332-A1 | INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION | Abbott Laboratories (US) | 2002-10-23 | — | — | EP | disclosed |
| WO-2001044223-A1 | INHIBITORS OF INTERLEUKIN 5 GENE EXPRESSION | ABBOTT LABORATORIES (US) | 2001-06-21 | — | — | WO | disclosed |