Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.39 |
| ▸ | MTOR | P42345 | 10/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL756425 | 0.80 | PIK3CA (0.57) | PIK3CAMTORPIK3CBSYKPIK3CD | |
| SCHEMBL752212 | 0.76 | PIK3CA (0.65) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL753783 | 0.70 | CACNA1B (0.48) | PIK3CAMTORPIK3CBSYKPIK3CD | |
| SCHEMBL765852 | 0.68 | PIK3CA (0.62) | PIK3CAMTORPIK3CB | |
| SCHEMBL752218 | 0.67 | PIK3CA (0.39) | PIK3CAMTORCDK2PIK3CB | |
| SCHEMBL28251967 | 0.60 | KMO (0.41) | — | |
| SCHEMBL4687035 | 0.58 | CHRNB2 (0.34) | — | |
| Trifluoroacetic Acid SCHEMBL750931 | 0.57 | PIK3CA (0.56) | PIK3CAMTORCDK4CCNE1CDK2 | |
| SCHEMBL11028413 | 0.57 | PIK3CA (0.56) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL164773 | 0.56 | PIK3CA (0.78) | PIK3CAMTORPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | disclosed |
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | AMGEN INC. (US) | 2012-07-26 | — | — | US | disclosed |
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | PIK3CA, PIKFYVE, PIK3CD | PIK3CA 1/4885MTOR 21/4885NTRK1 939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.