SCHEMBL7564700

SCHEMBL7564700

CCOC(=O)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)CCc2ccccc21

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 4/20 0.63
SCN9A Q15858 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7598390 1.00 CCKBR (0.63) CCKBRSCN9A
SCHEMBL7486156 0.92 CCKBR (0.72) CCKBRSCN9A
SCHEMBL7486160 0.92 CCKBR (0.72) CCKBRSCN9A
SCHEMBL7421691 0.91 CCKBR (0.51) CCKBR
SCHEMBL11182642 0.91 CCKBR (0.59) CCKBRSCN9A
SCHEMBL11050154 0.88 ACE (0.66) CCKBRSCN9A
SCHEMBL8673708 0.88 ACE (0.66) CCKBRSCN9A
SCHEMBL7084907 0.83 CCKBR (0.63) CCKBR
SCHEMBL7568437 0.83 CCKBR (0.46) CCKBR
SCHEMBL10499355 0.83 CCKBR (0.46) CCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4575503-A ANGIOTENSIN CONVERTING ENZYME INHIBITOR, HYPOTENSIVE CIBA-GEIGY CORPORATION (US) 1986-03-11 US disclosed
US-4473575-A ANGIOTENSIN INHIBITORS, HYPOTENSIVE AGENTS CIBA-GEIGY CORPORATION (US) 1984-09-25 US disclosed
US-4410520-A ANGIOTENSION CONVERTING ENZYME INGIBITOR, HYPOTENSIVE AGENTS CIBA-GEIGY CORPORATION (US) 1983-10-18 US disclosed
EP-0072352-A1 Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use CIBA-GEIGY AG (CH) 1983-02-16 EP disclosed