SCHEMBL7564974

SCHEMBL7564974

CC1=Cc2c(-c3ccccn3)cc(-c3ccccn3)cc2C1[Zr](Cl)(Cl)(C1C(C)=Cc2c(-c3ccccn3)cc(-c3ccccn3)cc21)[SiH](c1ccccc1)c1ccccc1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.31
NPC1 O15118 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7571571 0.91 KDM4E (0.30) KDM4ENPC1
SCHEMBL7565106 0.88 KDM4E (0.33) KDM4ENPC1
SCHEMBL7569884 0.86 ADRA1A (0.31)
SCHEMBL8673421 0.79 KDM4E (0.33) KDM4ENPC1
Hydrochloric Acid SCHEMBL7565111 0.79 KDM4E (0.34) KDM4ENPC1
SCHEMBL7566146 0.78 MAOA (0.31)
Hydrochloric Acid SCHEMBL7564984 0.78 KDM4E (0.32) KDM4ENPC1
SCHEMBL5951112 0.78 KDM4E (0.31) KDM4ENPC1
Hydrochloric Acid SCHEMBL7571576 0.77 KDM4E (0.32) KDM4ENPC1
SCHEMBL7566841 0.77 KDR (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5840947-A Organometallic compound TARGOR GMBH (DE) 1998-11-24 US claimed
EP-0743317-B1 Metallocenes comprising a heterocycle and catalysts containing them BASELL POLYOLEFINE GMBH (DE) 2002-08-28 EP disclosed
EP-0743317-A2 Metallocenes comprising a heterocycle and catalysts containing them HOECHST AKTIENGESELLSCHAFT (DE) 1996-11-20 EP disclosed