Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9536875 | 0.97 | ALOX5 (0.39) | LMNACYP2D6EPHX1HPGDALOX5 | |
| Acetic Acid SCHEMBL3477510 | 0.90 | LMNA (0.39) | LMNACYP2D6EPHX1HPGDALOX5 | |
| SCHEMBL20903 | 0.88 | — | — | |
| SCHEMBL16260127 | 0.88 | ESR1 (0.40) | CYP2D6EPHX1HPGDALOX5KMT2A | |
| SCHEMBL4986081 | 0.88 | ESR1 (0.40) | CYP2D6EPHX1HPGDALOX5KMT2A | |
| SCHEMBL13973760 | 0.88 | ESR1 (0.40) | CYP2D6EPHX1HPGDALOX5KMT2A | |
| SCHEMBL330190 | 0.88 | — | — | |
| SCHEMBL13646378 | 0.88 | ESR1 (0.40) | CYP2D6EPHX1HPGDALOX5KMT2A | |
| SCHEMBL14306984 | 0.88 | ESR1 (0.40) | CYP2D6EPHX1HPGDALOX5KMT2A | |
| SCHEMBL738125 | 0.88 | ESR1 (0.40) | CYP2D6EPHX1HPGDALOX5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456799-B1 | WATER-BORNE BINDERS FOR PRIMER-SURFACER COATING COMPOSITIONS | ALLNEX AUSTRIA GMBH (AT) | 2014-09-10 | — | — | EP | claimed |
| CN-113956642-B | PC/PBT composition with high weld mark strength and preparation method thereof | 万华化学（宁波）有限公司 | 2023-07-11 | — | — | CN | disclosed |
| EP-2583995-B1 | Metal-filled cast resin for producing a porous, resin-bonded moulding | HÜTHER ULRICH (DE) | 2015-12-16 | — | — | EP | disclosed |
| EP-2583995-A1 | Metal-filled cast resin for producing a porous, resin-bonded moulding | Hüther, Ulrich (DE) | 2013-04-24 | — | — | EP | disclosed |
| EP-0983220-B1 | METHOD FOR PRODUCING ALCOHOLS CONTAINING CYCLOALIPHATIC GROUPS | BASF AG (DE) | 2002-07-24 | — | — | EP | disclosed |
| EP-0068162-B1 | MODIFIED AMINOPLASTS, METHOD FOR THEIR PREPARATION AND THEIR APPLICATION | CASSELLA Aktiengesellschaft (DE) | 1986-10-15 | — | — | EP | disclosed |
| EP-0029972-B1 | PREPARATION FOR BRIGHTENING SYNTHETIC FIBRES, PROCESS FOR ITS PREPARATION AND PROCESS FOR OPTICAL BRIGHTENING | CASSELLA Aktiengesellschaft (DE) | 1984-09-19 | — | — | EP | disclosed |
| EP-0068162-A2 | Modified aminoplasts, method for their preparation and their application | CASSELLA Aktiengesellschaft (DE) | 1983-01-05 | — | — | EP | disclosed |
| EP-0000898-B1 | LEVELLING AGENT AND PROCESS FOR THE DYEING OF SYNTHETIC FIBROUS MATERIAL | CASSELLA Aktiengesellschaft (DE) | 1982-02-03 | — | — | EP | disclosed |
| EP-0001206-B1 | POLYCONDENSATE, PROCESS FOR ITS PREPARATION AND ITS USE AS LEVELLING AGENT IN DYEING SYNTHETIC FIBRE MATERIAL | CASSELLA Aktiengesellschaft (DE) | 1981-08-26 | — | — | EP | disclosed |
| EP-0029972-A2 | Preparation for brightening synthetic fibres, process for its preparation and process for optical brightening | CASSELLA Aktiengesellschaft (DE) | 1981-06-10 | — | — | EP | disclosed |
| EP-0013564-A1 | Water soluble and water dispersible polyester, process for its preparation and its use as egalising agent as well as egalising agent containing said polyester | CASSELLA Aktiengesellschaft (DE) | 1980-07-23 | — | — | EP | disclosed |
| US-4159943-A | Froth flotation of ores using hydrocarbyl bicarbonates | PETROVICH VOJISLAV | 1979-07-03 | — | — | US | disclosed |
| EP-0001206-A1 | Polycondensate, process for its preparation and its use as levelling agent in dyeing synthetic fibre material | CASSELLA Aktiengesellschaft (DE) | 1979-04-04 | — | — | EP | disclosed |
| EP-0000898-A1 | Levelling agent and process for the dyeing of synthetic fibrous material | CASSELLA Aktiengesellschaft (DE) | 1979-03-07 | — | — | EP | disclosed |