Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | KAT7 | O95251 | 1/20 | 0.42 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.39 |
| ▸ | FPR3 | P25089 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7695495 | 1.00 | ACHE (0.46) | ACHEGPR119SCN9AACKR3KAT7 | |
| SCHEMBL5870830 | 0.90 | ACHE (0.56) | ACHEACKR3KAT7KAT8CYP2C9 | |
| SCHEMBL7247703 | 0.81 | GPR119 (0.51) | GPR119USP30 | |
| SCHEMBL5870776 | 0.80 | ACKR3 (0.50) | ACHEACKR3KAT7KAT8USP30 | |
| SCHEMBL5870788 | 0.80 | ACKR3 (0.50) | ACHEACKR3KAT7KAT8USP30 | |
| SCHEMBL5871030 | 0.80 | ACKR3 (0.50) | ACHEACKR3KAT7KAT8USP30 | |
| SCHEMBL5870963 | 0.77 | KAT7 (0.46) | GPR119SCN9AACKR3KAT7KAT8 | |
| SCHEMBL7522770 | 0.76 | ACHE (0.55) | ACHEOPRM1KCNH2SIGMAR1 | |
| SCHEMBL9901066 | 0.76 | SCN9A (0.54) | GPR119SCN9AACKR3KAT7KAT8 | |
| SCHEMBL5870948 | 0.75 | CYP2C9 (0.46) | GPR119ACKR3CYP2C9ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002069895-A2 | HETEROCYCLIC ANALGESIC COMPOUNDS AND METHODS OF USE THEREOF | SEPRACOR, INC. (US) | 2002-09-12 | — | — | WO | disclosed |