Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 11/20 | 0.48 |
| ▸ | CTSS | P25774 | 11/20 | 0.48 |
| ▸ | CTSK | P43235 | 7/20 | 0.48 |
| ▸ | CTSB | P07858 | 4/20 | 0.48 |
| ▸ | GRN | P28799 | 1/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CTSH | P09668 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7539325 | 0.90 | CTSS (0.54) | CTSLCTSSCTSKCTSBMEN1 | |
| SCHEMBL5525335 | 0.84 | CTSL (0.69) | CTSLCTSSCTSKCTSBGRN | |
| SCHEMBL5530441 | 0.84 | CTSL (0.69) | CTSLCTSSCTSKCTSBGRN | |
| SCHEMBL7539158 | 0.83 | CTSL (0.55) | CTSLCTSSCTSKCTSBGRN | |
| SCHEMBL5518263 | 0.83 | CTSL (0.58) | CTSLCTSSCTSKCTSBGRN | |
| SCHEMBL5525443 | 0.82 | CTSL (0.55) | CTSLCTSSCTSKCTSB | |
| SCHEMBL5527644 | 0.82 | CTSS (0.72) | CTSLCTSSCTSKCTSBGRN | |
| SCHEMBL5528488 | 0.82 | CTSL (0.62) | CTSLCTSSCTSKCTSBGRN | |
| SCHEMBL5534137 | 0.82 | CTSL (0.49) | CTSLCTSSCTSKCTSBGRN | |
| SCHEMBL7531795 | 0.82 | CTSL (0.69) | CTSLCTSSCTSKCTSBGRN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178958-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000055125-A2 | N-CYANOMETHYL AMIDES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |