Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 6/20 | 0.60 |
| ▸ | TACR1 | P25103 | 6/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7566317 | 1.00 | TACR2 (0.60) | TACR2TACR1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL7555128 | 0.79 | TACR1 (0.59) | TACR2TACR1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL7555122 | 0.79 | TACR1 (0.59) | TACR2TACR1SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL22917998 | 0.67 | SLC6A4 (0.46) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL6950674 | 0.67 | BACE1 (0.45) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL20457210 | 0.66 | SLC6A4 (0.46) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL6968576 | 0.65 | TACR1 (0.45) | TACR2TACR1 | |
| SCHEMBL7137053 | 0.65 | TACR2 (0.59) | TACR2TACR1CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL7137046 | 0.65 | TACR2 (0.59) | TACR2TACR1CYP2D6CYP2C19CYP3A4 | |
| SCHEMBL6966843 | 0.64 | TACR1 (0.48) | TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888337-B1 | PIPERIDONE TACHYKININ ANTAGONISTS | PFIZER RES & DEV (IE) | 2002-06-05 | — | — | EP | disclosed |
| US-6262075-B1 | Piperidone tachykinin antagonists | PFIZER INC | 2001-07-17 | — | — | US | disclosed |