SCHEMBL7566541

SCHEMBL7566541

NCC=COCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 3/20 0.52
AGXT P21549 4/20 0.50
TSHR P16473 1/20 0.44
AOC3 Q16853 1/20 0.42
LOXL2 Q9Y4K0 2/20 0.41
MAOB P27338 3/20 0.40
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
MAOA P21397 1/20 0.38
RAB9A P51151 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
CYP2A6 P11509 1/20 0.38
HTR2A P28223 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27509183 0.82 TSHR (0.57) IDO1AGXTTSHRMAOBCA1
SCHEMBL17269304 0.81 MAOB (0.58) IDO1AGXTTSHRMAOBCA1
SCHEMBL1257815 0.79 IDO1 (0.46) IDO1AGXTTSHRMAOBCA1
SCHEMBL738243 0.79 IDO1 (0.46) IDO1AGXTTSHRMAOBCA1
SCHEMBL7717207 0.79 IDO1 (0.46) IDO1AGXTTSHRMAOBCA1
SCHEMBL675840 0.79 IDO1 (0.46) IDO1AGXTTSHRMAOBCA1
SCHEMBL7717208 0.79 IDO1 (0.46) IDO1AGXTTSHRMAOBCA1
SCHEMBL27744246 0.78 IDO1 (0.50) IDO1AGXTTSHRLOXL2MAOB
SCHEMBL23827883 0.78 IDO1 (0.50) IDO1AGXTTSHRLOXL2MAOB
SCHEMBL23827882 0.78 IDO1 (0.50) IDO1AGXTTSHRLOXL2MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1212301-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS Targacept, Inc. (US) 2002-06-12 EP disclosed
WO-2001016107-A1 ARYLALKYLOXYALKYLAMINES AND ARYLALKYLTHIOALKYLAMINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS TARGACEPT, INC. (US) 2001-03-08 WO disclosed